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    ANTKMT adenine nucleotide translocase lysine methyltransferase [ Homo sapiens (human) ]

    Gene ID: 65990, updated on 23-Nov-2021

    Summary

    Official Symbol
    ANTKMTprovided by HGNC
    Official Full Name
    adenine nucleotide translocase lysine methyltransferaseprovided by HGNC
    Primary source
    HGNC:HGNC:14152
    See related
    Ensembl:ENSG00000103254 MIM:618566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANT-KMT; FAM173A; C16orf24
    Expression
    Broad expression in kidney (RPKM 5.7), colon (RPKM 4.4) and 22 other tissues See more
    Orthologs
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    Genomic context

    See ANTKMT in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (720581..722590)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (771146..772590)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 16 Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene coiled-coil domain containing 78 Neighboring gene hydroxyacylglutathione hydrolase like Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene Sharpr-MPRA regulatory region 977

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC2494

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein-lysine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adenine nucleotide translocase lysine N-methyltransferase
    Names
    family with sequence similarity 173 member A
    protein FAM173A
    protein N-lysine methyltransferase FAM173A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271285.2NP_001258214.1  adenine nucleotide translocase lysine N-methyltransferase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AI492179, BI597021, BI838160
      Consensus CDS
      CCDS59254.1
      UniProtKB/TrEMBL
      J3KMW5
      Related
      ENSP00000219535.3, ENST00000219535.7
      Conserved Domains (1) summary
      COG2890
      Location:65123
      HemK; Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]
    2. NM_023933.3NP_076422.1  adenine nucleotide translocase lysine N-methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_076422.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AI492179, BC002624, BI597021
      Consensus CDS
      CCDS10423.1
      UniProtKB/Swiss-Prot
      Q9BQD7
      Related
      ENSP00000454380.1, ENST00000569529.6
      Conserved Domains (1) summary
      COG2890
      Location:65123
      HemK; Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      720581..722590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_243298.4 RNA Sequence

      Related
      ENST00000566525.5
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