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    SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [ Homo sapiens (human) ]

    Gene ID: 6597, updated on 8-Jul-2021

    Summary

    Official Symbol
    SMARCA4provided by HGNC
    Official Full Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4provided by HGNC
    Primary source
    HGNC:HGNC:11100
    See related
    Ensembl:ENSG00000127616 MIM:603254
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRG1; CSS4; SNF2; SWI2; MRD16; RTPS2; BAF190; SNF2L4; SNF2LB; hSNF2b; BAF190A; SNF2-beta
    Summary
    The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
    Expression
    Ubiquitous expression in testis (RPKM 21.8), brain (RPKM 14.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SMARCA4 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10960999..11062277)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11071706..11172949)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene coactivator associated arginine methyltransferase 1 Neighboring gene Yip1 domain family member 2 Neighboring gene translocase of inner mitochondrial membrane 29 Neighboring gene RNA, 7SL, cytoplasmic 192, pseudogene Neighboring gene LDLR antisense RNA 1 Neighboring gene low density lipoprotein receptor Neighboring gene microRNA 6886

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
    GeneReviews: Not available
    Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
    GeneReviews: Not available
    Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
    GeneReviews: Not available
    Mental retardation, autosomal dominant 16
    MedGen: C3553249 OMIM: 614609 GeneReviews: Not available
    Compare labs
    Rhabdoid tumor predisposition syndrome 2 Compare labs
    Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
    GeneReviews: Not available

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2013-09-04)

    ClinGen Genome Curation Page
    Haploinsufficency

    Some evidence for dosage pathogenicity (Last evaluated 2013-09-04)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Most of the components of the SWI2/SNF2 chromatin remodeling complex (BRG1/BRM, BAF250, BAF180, BAF170, BAF155, BAF60a, BAF53A, actin and InI) except BRM, BAF155 and BAF57, are identified to interact with HIV-1 Tat in Jurkat cell PubMed
    tat HIV-1 Tat induces phosphorylation of BRG1 and BAF155 PubMed
    tat INI-1 and BRG-1 synergize with the p300 acetyltransferase to activate the HIV promoter; this synergism depends on the acetyltransferase activity of p300 and on HIV-1 Tat amino acids Lys(50) and Lys(51), suggesting a regulation of Tat by these proteins PubMed
    tat Acetylated HIV-1 Tat binds efficiently to BRG1 and BAF200 (component of PBAF complex) and weakly to BAF250 (component of BAF complex) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ39786

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATPase, acting on DNA IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to RNA polymerase I core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Tat protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables androgen receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lysine-acetylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to nucleosomal DNA binding HDA PubMed 
    enables nucleosome-dependent ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables transcription coregulator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ATP-dependent chromatin remodeling HDA PubMed 
    involved_in ATP-dependent chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in RNA polymerase I preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IC
    Inferred by Curator
    more info
    PubMed 
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural retina development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation by host of viral transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of glucose mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of pri-miRNA transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin HDA PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space HDA PubMed 
    located_in membrane HDA PubMed 
    part_of nBAF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of npBAF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of npBAF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex HDA PubMed 

    General protein information

    Preferred Names
    transcription activator BRG1
    Names
    ATP-dependent helicase SMARCA4
    BRG1-associated factor 190A
    BRM/SWI2-related gene 1
    SNF2-like 4
    brahma protein-like 1
    global transcription activator homologous sequence
    homeotic gene regulator
    mitotic growth and transcription activator
    nuclear protein GRB1
    protein BRG-1
    protein brahma homolog 1
    sucrose nonfermenting-like 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011556.3 RefSeqGene

      Range
      5099..106342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_878

    mRNA and Protein(s)

    1. NM_001128844.3NP_001122316.1  transcription activator BRG1 isoform B

      See identical proteins and their annotated locations for NP_001122316.1

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS12253.1
      UniProtKB/Swiss-Prot
      P51532
      UniProtKB/TrEMBL
      A7E2E1
      Related
      ENSP00000395654.1, ENST00000429416.8
      Conserved Domains (9) summary
      cd05516
      Location:14581564
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13231389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    2. NM_001128845.2NP_001122317.1  transcription activator BRG1 isoform C

      See identical proteins and their annotated locations for NP_001122317.1

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS45972.1
      UniProtKB/Swiss-Prot
      P51532
      UniProtKB/TrEMBL
      B3KNW7
      Conserved Domains (8) summary
      cd05516
      Location:14281534
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      pfam08880
      Location:171205
      QLQ; QLQ
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14619
      Location:12891356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl25732
      Location:370552
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26465
      Location:7501232
      SNF2_N; SNF2 family N-terminal domain
    3. NM_001128846.2NP_001122318.1  transcription activator BRG1 isoform D

      See identical proteins and their annotated locations for NP_001122318.1

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS45973.1
      UniProtKB/Swiss-Prot
      P51532
      UniProtKB/TrEMBL
      B3KNW7
      Related
      ENSP00000464778.1, ENST00000589677.5
      Conserved Domains (8) summary
      cd05516
      Location:14281533
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      pfam08880
      Location:171205
      QLQ; QLQ
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14619
      Location:12891356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl25732
      Location:370552
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26465
      Location:7501232
      SNF2_N; SNF2 family N-terminal domain
    4. NM_001128847.4NP_001122319.1  transcription activator BRG1 isoform E

      See identical proteins and their annotated locations for NP_001122319.1

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS54217.1
      UniProtKB/Swiss-Prot
      P51532
      UniProtKB/TrEMBL
      B3KNW7
      Related
      ENSP00000494676.1, ENST00000647230.1
      Conserved Domains (9) summary
      cd05516
      Location:14251531
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:12901356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    5. NM_001128848.2NP_001122320.1  transcription activator BRG1 isoform F

      See identical proteins and their annotated locations for NP_001122320.1

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS54218.1
      UniProtKB/Swiss-Prot
      P51532
      UniProtKB/TrEMBL
      B3KNW7
      Related
      ENSP00000392837.2, ENST00000444061.8
      Conserved Domains (9) summary
      cd05516
      Location:14251530
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:12901356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    6. NM_001128849.3NP_001122321.1  transcription activator BRG1 isoform A

      See identical proteins and their annotated locations for NP_001122321.1

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      UniProtKB/TrEMBL
      Q9HBD4
      Conserved Domains (9) summary
      cd05516
      Location:14901596
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13231389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    7. NM_001374457.1NP_001361386.1  transcription activator BRG1 isoform E

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Related
      ENSP00000495536.1, ENST00000646484.1
      Conserved Domains (9) summary
      cd05516
      Location:14251531
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:12901356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    8. NM_001387283.1NP_001374212.1  transcription activator BRG1 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Related
      ENSP00000495368.1, ENST00000646693.2
      Conserved Domains (9) summary
      cd05516
      Location:14901596
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13231389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    9. NM_003072.5NP_003063.2  transcription activator BRG1 isoform B

      See identical proteins and their annotated locations for NP_003063.2

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS12253.1
      UniProtKB/Swiss-Prot
      P51532
      UniProtKB/TrEMBL
      A7E2E1
      Related
      ENSP00000343896.4, ENST00000344626.10
      Conserved Domains (9) summary
      cd05516
      Location:14581564
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13231389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    RNA

    1. NR_164683.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      10960999..11062277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451659.1XP_024307427.1  transcription activator BRG1 isoform X2

      Conserved Domains (9) summary
      cd05516
      Location:14901595
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13231389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    2. XM_024451660.1XP_024307428.1  transcription activator BRG1 isoform X3

      Related
      ENSP00000496004.1, ENST00000643995.1
      Conserved Domains (9) summary
      cd05516
      Location:14611567
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13231389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    3. XM_024451662.1XP_024307430.1  transcription activator BRG1 isoform X5

      Conserved Domains (9) summary
      cd05516
      Location:14581563
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13231389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    4. XM_024451661.1XP_024307429.1  transcription activator BRG1 isoform X4

      Related
      ENSP00000496498.1, ENST00000642628.1
      Conserved Domains (9) summary
      cd05516
      Location:14571563
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:12901356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    5. XM_024451663.1XP_024307431.1  transcription activator BRG1 isoform X6

      Conserved Domains (8) summary
      cd05516
      Location:14571562
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      pfam08880
      Location:171205
      QLQ; QLQ
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14619
      Location:12891356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl25732
      Location:370552
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26465
      Location:7501232
      SNF2_N; SNF2 family N-terminal domain
    6. XM_024451664.1XP_024307432.1  transcription activator BRG1 isoform X7

      Related
      ENSP00000496635.1, ENST00000643296.1
      Conserved Domains (8) summary
      cd05516
      Location:14281534
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      pfam08880
      Location:171205
      QLQ; QLQ
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14619
      Location:12891356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl25732
      Location:370552
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26465
      Location:7501232
      SNF2_N; SNF2 family N-terminal domain
    7. XM_024451665.1XP_024307433.1  transcription activator BRG1 isoform X8

      Conserved Domains (8) summary
      cd05516
      Location:14281533
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612656
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      pfam08880
      Location:171205
      QLQ; QLQ
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14619
      Location:12891356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl25732
      Location:370552
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26465
      Location:7501232
      SNF2_N; SNF2 family N-terminal domain
    8. XM_024451667.1XP_024307435.1  transcription activator BRG1 isoform X10

      Related
      ENSP00000494463.1, ENST00000645460.1
      Conserved Domains (9) summary
      cd05516
      Location:14251530
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:12901356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    9. XM_011528198.1XP_011526500.1  transcription activator BRG1 isoform X1

      See identical proteins and their annotated locations for XP_011526500.1

      UniProtKB/TrEMBL
      Q9HBD4
      Conserved Domains (9) summary
      cd05516
      Location:14901596
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13231389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    10. XM_024451658.1XP_024307426.1  transcription activator BRG1 isoform X1

      Conserved Domains (9) summary
      cd05516
      Location:14901596
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13231389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
    11. XM_006722846.2XP_006722909.1  transcription activator BRG1 isoform X1

      See identical proteins and their annotated locations for XP_006722909.1

      UniProtKB/TrEMBL
      Q9HBD4
      Conserved Domains (9) summary
      cd05516
      Location:14901596
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:7501232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612654
      BRK; BRK domain
      pfam08880
      Location:171205
      QLQ
      pfam14619
      Location:13231389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
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