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    SLC22A2 solute carrier family 22 member 2 [ Homo sapiens (human) ]

    Gene ID: 6582, updated on 17-Jun-2024

    Summary

    Official Symbol
    SLC22A2provided by HGNC
    Official Full Name
    solute carrier family 22 member 2provided by HGNC
    Primary source
    HGNC:HGNC:10966
    See related
    Ensembl:ENSG00000112499 MIM:602608; AllianceGenome:HGNC:10966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OCT2
    Summary
    Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward kidney (RPKM 70.1) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC22A2 in Genome Data Viewer
    Location:
    6q25.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (160216755..160258821, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (161462946..161508769, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (160637787..160679853, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:160554924-160556123 Neighboring gene solute carrier family 22 member 1 Neighboring gene mitochondrial import receptor subunit TOM6 homolog Neighboring gene MPRA-validated peak6287 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:160647818-160648746 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:160660268-160661163 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:160661164-160662058 Neighboring gene uncharacterized LOC105378088 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:160694323-160695522 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:160719355-160719855 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:160720893-160721479 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:160724446-160724946 Neighboring gene uncharacterized LOC124901453 Neighboring gene solute carrier family 22 member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:160807441-160807942

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog
    Genetic loci influencing kidney function and chronic kidney disease.
    EBI GWAS Catalog
    New loci associated with kidney function and chronic kidney disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC32628

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables L-arginine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables acetylcholine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables amine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables choline transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables efflux transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monoamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neurotransmitter transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neurotransmitter transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables organic cation transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables organic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables organic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables organic cation transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables organic cation transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    enables prostaglandin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables putrescine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pyrimidine nucleoside transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables quaternary ammonium group transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables spermidine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables thiamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables toxin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables toxin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables xenobiotic transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables xenobiotic transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-arginine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-arginine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in acetylcholine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in amine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in amino acid import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in body fluid secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular detoxification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular detoxification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in choline transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dopamine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dopamine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dopamine uptake IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epinephrine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epinephrine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histamine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histamine uptake IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neurotransmitter transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurotransmitter transport TAS
    Traceable Author Statement
    more info
     
    involved_in norepinephrine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in norepinephrine uptake IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in norepinephrine uptake TAS
    Traceable Author Statement
    more info
     
    involved_in organic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within organic cation transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in organic cation transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in organic cation transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in prostaglandin transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in purine-containing compound transmembrane transport TAS
    Traceable Author Statement
    more info
     
    involved_in putrescine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in quaternary ammonium group transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in serotonin transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in serotonin uptake IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in spermidine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermidine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in thiamine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transport across blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in xenobiotic transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in xenobiotic transport across blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    solute carrier family 22 member 2
    Names
    organic cation transporter 2
    solute carrier family 22 (organic cation transporter), member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003058.4NP_003049.2  solute carrier family 22 member 2

      See identical proteins and their annotated locations for NP_003049.2

      Status: REVIEWED

      Source sequence(s)
      AL162582
      Consensus CDS
      CCDS5276.1
      UniProtKB/Swiss-Prot
      O15244, Q5T7Q6, Q6PIQ8, Q8NG62, Q9NQB9
      Related
      ENSP00000355920.3, ENST00000366953.8
      Conserved Domains (2) summary
      cd06174
      Location:124492
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:13525
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      160216755..160258821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      161462946..161508769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153191.1: Suppressed sequence

      Description
      NM_153191.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.