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    SLC20A2 solute carrier family 20 member 2 [ Homo sapiens (human) ]

    Gene ID: 6575, updated on 2-Aug-2021

    Summary

    Official Symbol
    SLC20A2provided by HGNC
    Official Full Name
    solute carrier family 20 member 2provided by HGNC
    Primary source
    HGNC:HGNC:10947
    See related
    Ensembl:ENSG00000168575 MIM:158378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIT2; RAM1; GLVR2; IBGC1; IBGC2; IBGC3; MLVAR; PIT-2; Ram-1; GLVR-2
    Summary
    This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
    Expression
    Ubiquitous expression in thyroid (RPKM 23.3), heart (RPKM 12.0) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SLC20A2 in Genome Data Viewer
    Location:
    8p11.21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (42416475..42542143, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (42273993..42397097, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene dickkopf WNT signaling pathway inhibitor 4 Neighboring gene voltage dependent anion channel 3 Neighboring gene Sharpr-MPRA regulatory region 9023 Neighboring gene small integral membrane protein 19 Neighboring gene uncharacterized LOC105379396 Neighboring gene cholinergic receptor nicotinic beta 3 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables inorganic phosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables sodium:phosphate symporter activity TAS
    Traceable Author Statement
    more info
     
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ion transport TAS
    Traceable Author Statement
    more info
     
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    sodium-dependent phosphate transporter 2
    Names
    epididymis secretory sperm binding protein
    gibbon ape leukemia virus receptor 2
    murine leukemia virus, amphotropic, receptor for
    murine leukemia virus, amphotropic; receptor
    solute carrier family 20 (phosphate transporter), member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032161.1 RefSeqGene

      Range
      5260..128364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001257180.2NP_001244109.1  sodium-dependent phosphate transporter 2

      See identical proteins and their annotated locations for NP_001244109.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK291202, BC028600, H10927
      Consensus CDS
      CCDS6132.1
      UniProtKB/Swiss-Prot
      Q08357
      Related
      ENSP00000429754.1, ENST00000520262.6
      Conserved Domains (2) summary
      COG0306
      Location:7224
      PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
      pfam01384
      Location:491637
      PHO4; Phosphate transporter family
    2. NM_001257181.2NP_001244110.1  sodium-dependent phosphate transporter 2

      See identical proteins and their annotated locations for NP_001244110.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK295952, AK314774, BC028600, H10927
      Consensus CDS
      CCDS6132.1
      UniProtKB/Swiss-Prot
      Q08357
      UniProtKB/TrEMBL
      B2RBR4, B4DJ71
      Related
      ENSP00000429712.1, ENST00000520179.5
      Conserved Domains (2) summary
      COG0306
      Location:7224
      PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
      pfam01384
      Location:491637
      PHO4; Phosphate transporter family
    3. NM_006749.5NP_006740.1  sodium-dependent phosphate transporter 2

      See identical proteins and their annotated locations for NP_006740.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC028600, DA418477, H10927, L20852
      Consensus CDS
      CCDS6132.1
      UniProtKB/Swiss-Prot
      Q08357
      Related
      ENSP00000340465.3, ENST00000342228.7
      Conserved Domains (2) summary
      COG0306
      Location:7224
      PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
      pfam01384
      Location:491637
      PHO4; Phosphate transporter family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      42416475..42542143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013748.1XP_016869237.1  sodium-dependent phosphate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      Q08357
      Conserved Domains (2) summary
      COG0306
      Location:7224
      PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
      pfam01384
      Location:491637
      PHO4; Phosphate transporter family
    2. XM_005273613.4XP_005273670.1  sodium-dependent phosphate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_005273670.1

      UniProtKB/Swiss-Prot
      Q08357
      Conserved Domains (2) summary
      COG0306
      Location:7224
      PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
      pfam01384
      Location:491637
      PHO4; Phosphate transporter family
    3. XM_024447235.1XP_024303003.1  sodium-dependent phosphate transporter 2 isoform X1

      Conserved Domains (2) summary
      COG0306
      Location:7224
      PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
      pfam01384
      Location:491637
      PHO4; Phosphate transporter family
    4. XM_024447236.1XP_024303004.1  sodium-dependent phosphate transporter 2 isoform X1

      Conserved Domains (2) summary
      COG0306
      Location:7224
      PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
      pfam01384
      Location:491637
      PHO4; Phosphate transporter family
    5. XM_017013752.2XP_016869241.1  sodium-dependent phosphate transporter 2 isoform X4

      Conserved Domains (2) summary
      COG0306
      Location:349507
      PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
      pfam01384
      Location:401499
      PHO4; Phosphate transporter family
    6. XM_024447237.1XP_024303005.1  sodium-dependent phosphate transporter 2 isoform X3

      Conserved Domains (2) summary
      pfam01384
      Location:444590
      PHO4; Phosphate transporter family
      cl27575
      Location:7177
      PHO4; Phosphate transporter family
    7. XM_006716390.4XP_006716453.1  sodium-dependent phosphate transporter 2 isoform X3

      Conserved Domains (2) summary
      pfam01384
      Location:444590
      PHO4; Phosphate transporter family
      cl27575
      Location:7177
      PHO4; Phosphate transporter family
    8. XM_017013750.2XP_016869239.1  sodium-dependent phosphate transporter 2 isoform X4

      Conserved Domains (2) summary
      COG0306
      Location:349507
      PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
      pfam01384
      Location:401499
      PHO4; Phosphate transporter family
    9. XM_017013751.2XP_016869240.1  sodium-dependent phosphate transporter 2 isoform X4

      Conserved Domains (2) summary
      COG0306
      Location:349507
      PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
      pfam01384
      Location:401499
      PHO4; Phosphate transporter family
    10. XM_017013749.2XP_016869238.1  sodium-dependent phosphate transporter 2 isoform X3

      Conserved Domains (2) summary
      pfam01384
      Location:444590
      PHO4; Phosphate transporter family
      cl27575
      Location:7177
      PHO4; Phosphate transporter family
    11. XM_006716391.4XP_006716454.1  sodium-dependent phosphate transporter 2 isoform X4

      Conserved Domains (2) summary
      COG0306
      Location:349507
      PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
      pfam01384
      Location:401499
      PHO4; Phosphate transporter family
    12. XM_005273615.4XP_005273672.1  sodium-dependent phosphate transporter 2 isoform X2

      Conserved Domains (2) summary
      COG0306
      Location:7224
      PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
      pfam01384
      Location:27131
      PHO4; Phosphate transporter family
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