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    SLC9A5 solute carrier family 9 member A5 [ Homo sapiens (human) ]

    Gene ID: 6553, updated on 17-Jun-2024

    Summary

    Official Symbol
    SLC9A5provided by HGNC
    Official Full Name
    solute carrier family 9 member A5provided by HGNC
    Primary source
    HGNC:HGNC:11078
    See related
    Ensembl:ENSG00000135740 MIM:600477; AllianceGenome:HGNC:11078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NHE5
    Summary
    Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Implicated in end stage renal disease. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen (RPKM 6.3), testis (RPKM 2.2) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SLC9A5 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67248979..67272191)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73043264..73066486)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67282882..67306094)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67265259-67265760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67265761-67266260 Neighboring gene transmembrane protein 208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7594 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:67271286-67272485 Neighboring gene formin homology 2 domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67275498-67276171 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67276172-67276844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67279559-67280218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7597 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67282619-67283120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67283121-67283620 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67287038-67287220 Neighboring gene uncharacterized LOC124903701 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67304537-67304794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7600 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67313287-67313468 Neighboring gene pleckstrin homology and RhoGEF domain containing G4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67318282-67319022 Neighboring gene potassium channel tetramerization domain containing 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10963 Neighboring gene RN7SK pseudogene 118

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef EIPA, a potent and specific inhibitor of Na+/H+ exchanger activity, significantly inhibits the Nef internalization into M2-macrophages, indicating that Nef is imported by Na+/H+ exchanger (solute carrier family 9, subfamily A) PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables arrestin family protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium:proton antiporter activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in monoatomic ion transport TAS
    Traceable Author Statement
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of intracellular pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in dendritic spine membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in neuron spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium/hydrogen exchanger 5
    Names
    NHE-5
    Na(+)/H(+) exchanger 5
    solute carrier family 9 (sodium/hydrogen exchanger), member 5
    solute carrier family 9 member 5
    solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323971.2NP_001310900.1  sodium/hydrogen exchanger 5 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC040160
      Conserved Domains (1) summary
      TIGR00840
      Location:41573
      b_cpa1; sodium/hydrogen exchanger 3
    2. NM_001323972.2NP_001310901.1  sodium/hydrogen exchanger 5 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC040160
    3. NM_001323973.2NP_001310902.1  sodium/hydrogen exchanger 5 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC040160
      Conserved Domains (2) summary
      TIGR00840
      Location:41630
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:50455
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    4. NM_001323974.2NP_001310903.1  sodium/hydrogen exchanger 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC040160
    5. NM_001323975.2NP_001310904.1  sodium/hydrogen exchanger 5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC040160
      Conserved Domains (2) summary
      TIGR00840
      Location:1335
      b_cpa1; sodium/hydrogen exchanger 3
      cl01133
      Location:1160
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    6. NM_004594.3NP_004585.1  sodium/hydrogen exchanger 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_004585.1

      Status: VALIDATED

      Source sequence(s)
      AF111173, AL137689, DB475730
      Consensus CDS
      CCDS42178.1
      UniProtKB/Swiss-Prot
      A5PKY7, Q14940, Q9Y626
      Related
      ENSP00000299798.11, ENST00000299798.16
      Conserved Domains (1) summary
      cl25615
      Location:41630
      NhaP2; NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism]

    RNA

    1. NR_136664.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC040160
    2. NR_136665.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC040160
      Related
      ENST00000564812.5
    3. NR_136666.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC040160
    4. NR_136667.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC040160

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67248979..67272191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434520.1XP_047290476.1  sodium/hydrogen exchanger 5 isoform X2

    2. XM_017023594.2XP_016879083.1  sodium/hydrogen exchanger 5 isoform X3

    3. XM_047434519.1XP_047290475.1  sodium/hydrogen exchanger 5 isoform X1

    4. XM_047434521.1XP_047290477.1  sodium/hydrogen exchanger 5 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      73043264..73066486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313756.1XP_054169731.1  sodium/hydrogen exchanger 5 isoform X2

    2. XM_054313757.1XP_054169732.1  sodium/hydrogen exchanger 5 isoform X3

    3. XM_054313755.1XP_054169730.1  sodium/hydrogen exchanger 5 isoform X1

    4. XM_054313758.1XP_054169733.1  sodium/hydrogen exchanger 5 isoform X4