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    BOLA2B bolA family member 2B [ Homo sapiens (human) ]

    Gene ID: 654483, updated on 5-Jan-2022

    Summary

    Official Symbol
    BOLA2Bprovided by HGNC
    Official Full Name
    bolA family member 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:32479
    See related
    Ensembl:ENSG00000169627
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BOLA2
    Summary
    This gene is located within a region of a segmental duplication on chromosome 16 and is identical to BOLA2 (bolA family member 2). The product of this gene belongs to a family of proteins that are widely conserved and may be involved in iron maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in duodenum (RPKM 28.0), small intestine (RPKM 24.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See BOLA2B in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (30192932..30193666, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30204253..30204987, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CORO1A antisense RNA 1 Neighboring gene coronin 1A Neighboring gene Sharpr-MPRA regulatory region 7413 Neighboring gene SLX1A-SULT1A3 readthrough (NMD candidate) Neighboring gene SLX1 homolog A, structure-specific endonuclease subunit Neighboring gene sulfotransferase family 1A member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron-sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of iron-sulfur cluster assembly complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    bolA-like protein 2
    Names
    BolA-like protein 2 member B
    bolA homolog 2B
    bolA-like protein 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039182.4NP_001034271.2  bolA-like protein 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC106782, BC137532
      Consensus CDS
      CCDS32430.1
      Related
      ENSP00000498355.1, ENST00000651894.2
      Conserved Domains (1) summary
      pfam01722
      Location:1279
      BolA; BolA-like protein
    2. NM_001320607.3NP_001307536.2  bolA-like protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct, shorter C-terminus than isoform 1.
      Source sequence(s)
      AC106782, BU960186
      Related
      ENSP00000455468.2, ENST00000569282.2

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      30192932..30193666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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