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    XAGE1B X antigen family member 1B [ Homo sapiens (human) ]

    Gene ID: 653067, updated on 5-Mar-2024

    Summary

    Official Symbol
    XAGE1Bprovided by HGNC
    Official Full Name
    X antigen family member 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:25400
    See related
    Ensembl:ENSG00000204382 MIM:300289; AllianceGenome:HGNC:25400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CTP9; XAGE1; CT12.1; GAGED2; XAGE-1; XAGE1C; XAGE1D; XAGE1E; CT12.1C; CT12.1D; CT12.1E; CT12.1b
    Summary
    This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010]
    Annotation information
    Note: There are two XAGE1 loci on the X chromosome. This location, previously annotated as XAGE1E, is now annotated as XAGE1B. [01 Dec 2017]
    Expression
    Restricted expression toward testis (RPKM 23.6) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See XAGE1B in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (52512077..52517068, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (51783841..51788832, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (52541053..52546044, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene X antigen family member 1A Neighboring gene RNA binding motif protein 22 pseudogene 7 Neighboring gene RNA binding motif protein 22 pseudogene 11 Neighboring gene X antigen family member 5-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    X antigen family member 1
    Names
    G antigen family D member 2
    X antigen family member 1E
    X antigen family, member 1C
    X antigen family, member 1D
    cancer/testis antigen 12.1
    cancer/testis antigen family 12, member 1b
    cancer/testis antigen family 12, member 1c
    cancer/testis antigen family 12, member 1d
    cancer/testis antigen family 12, member 1e
    cancer/testis associated protein
    protein XAGE-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029951.2 RefSeqGene

      Range
      5126..10112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001097604.3NP_001091073.2  X antigen family member 1 isoform a

      See identical proteins and their annotated locations for NP_001091073.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a, also known as XAGE-1b) encodes the longer isoform (a, also known as isoform XAGE-1b).
      Source sequence(s)
      BX510359
      Consensus CDS
      CCDS48126.2
      UniProtKB/Swiss-Prot
      A6NJ94, Q5JPN8, Q5JPP0, Q5JPP3, Q8WWG5, Q8WWG6, Q969J6, Q9HD64
      Related
      ENSP00000364766.1, ENST00000375616.6
      Conserved Domains (1) summary
      pfam05831
      Location:5575
      GAGE; GAGE protein
    2. NM_001097605.2NP_001091074.1  X antigen family member 1 isoform d

      See identical proteins and their annotated locations for NP_001091074.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d, also known as XAGE-1d) starts at a downstream transcription start site, and uses an alternate splice site in an internal exon that causes a frameshift in the 3' coding region, compared to variant a. The encoded isoform (d) has a distinct and shorter C-terminus, compared to isoform a.
      Source sequence(s)
      BX510359
      Consensus CDS
      CCDS48128.1
      UniProtKB/Swiss-Prot
      Q9HD64
      Related
      ENSP00000364763.3, ENST00000375613.7

    RNA

    1. NR_033257.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c, also known as XAGE-1c) differs in the 5'-most exon, compared to variant a. This variant is represented as non-coding due to the presence of two upstream ORFs that inhibit translation of the primary ORF, as indicated by experimental evidence in PMID:17335148.
      Source sequence(s)
      BX510359
      Related
      ENST00000375612.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      52512077..52517068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029746.2XP_016885235.1  X antigen family member 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      51783841..51788832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327618.1XP_054183593.1  X antigen family member 1 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001097597.2: Suppressed sequence

      Description
      NM_001097597.2: This RefSeq was permanently suppressed because it is a redundant RefSeq for this XAGE1 family member.
    2. NM_001097598.2: Suppressed sequence

      Description
      NM_001097598.2: This RefSeq was permanently suppressed because it is a redundant RefSeq for this XAGE1 family member.
    3. NM_001097602.1: Suppressed sequence

      Description
      NM_001097602.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    4. NM_001097603.1: Suppressed sequence

      Description
      NM_001097603.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    5. NM_020411.2: Suppressed sequence

      Description
      NM_020411.2: This RefSeq was permanently suppressed because it is a redundant RefSeq for this XAGE1 family member.
    6. NM_133430.2: Suppressed sequence

      Description
      NM_133430.2: This RefSeq was permanently suppressed because it is a redundant RefSeq for this XAGE1 family member.
    7. NM_133431.3: Suppressed sequence

      Description
      NM_133431.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.