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    RTN4R reticulon 4 receptor [ Homo sapiens (human) ]

    Gene ID: 65078, updated on 5-Mar-2024

    Summary

    Official Symbol
    RTN4Rprovided by HGNC
    Official Full Name
    reticulon 4 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:18601
    See related
    Ensembl:ENSG00000040608 MIM:605566; AllianceGenome:HGNC:18601
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NGR; NOGOR
    Summary
    This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 7.7), spleen (RPKM 2.5) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RTN4R in Genome Data Viewer
    Location:
    22q11.21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20241415..20268318, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20621207..20649434, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20228938..20255841, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905083 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20210507-20211174 Neighboring gene uncharacterized LOC105372863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20218512-20219305 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20225493-20226085 Neighboring gene Sharpr-MPRA regulatory region 11316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20230230-20230822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18673 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20234375-20234965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20235693-20236294 Neighboring gene microRNA 1286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20243726-20244270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20254685-20255373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13487 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20262187-20262687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20269715-20270454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20270455-20271195 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20271196-20271935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20280047-20280548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20285530-20286031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13492 Neighboring gene proline dehydrogenase like, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20300941-20301496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20301497-20302050 Neighboring gene Sharpr-MPRA regulatory region 9836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13493 Neighboring gene DiGeorge syndrome critical region gene 6 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Schizophrenia
    MedGen: C0036341 OMIM: 181500 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chondroitin sulfate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ganglioside GM1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ganglioside GM1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ganglioside GT1b binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ganglioside GT1b binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables neuregulin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in corpus callosum development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of axon regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuronal signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axonal growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic shaft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    reticulon-4 receptor
    Names
    Nogo-66 receptor
    UNQ330/PRO526
    nogo receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012176.2 RefSeqGene

      Range
      4976..31879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_023004.6NP_075380.1  reticulon-4 receptor precursor

      See identical proteins and their annotated locations for NP_075380.1

      Status: REVIEWED

      Source sequence(s)
      AC007663, AL834449, BM762412
      Consensus CDS
      CCDS13777.1
      UniProtKB/Swiss-Prot
      D3DX28, Q9BZR6
      UniProtKB/TrEMBL
      H7C0V4
      Related
      ENSP00000043402.7, ENST00000043402.8
      Conserved Domains (4) summary
      sd00033
      Location:6082
      LRR_RI; leucine-rich repeat [structural motif]
      pfam04094
      Location:332417
      DUF390; Protein of unknown function (DUF390)
      pfam13855
      Location:156214
      LRR_8; Leucine rich repeat
      cl15307
      Location:260296
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      20241415..20268318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      20621207..20649434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)