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    SKP1 S-phase kinase associated protein 1 [ Homo sapiens (human) ]

    Gene ID: 6500, updated on 17-Jun-2024

    Summary

    Official Symbol
    SKP1provided by HGNC
    Official Full Name
    S-phase kinase associated protein 1provided by HGNC
    Primary source
    HGNC:HGNC:10899
    See related
    Ensembl:ENSG00000113558 MIM:601434; AllianceGenome:HGNC:10899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L
    Summary
    This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 102.0), thyroid (RPKM 75.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SKP1 in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (134148935..134176950, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (134672565..134700570, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133484626..133512641, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 1 Neighboring gene short transmembrane mitochondrial protein 1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133422388-133422888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133422889-133423389 Neighboring gene Sharpr-MPRA regulatory region 10905 Neighboring gene Sharpr-MPRA regulatory region 12956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133437181-133438148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133438510-133439380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133441120-133441988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133442973-133443520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23127 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133457701-133458202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133464814-133465636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133465637-133466458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23129 Neighboring gene transcription factor 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133475053-133476030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:133513545-133514059 Neighboring gene protein phosphatase 2 catalytic subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23139 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133561503-133562022 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:133562023-133562544 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:133562545-133563064 Neighboring gene PPP2CA divergent transcript Neighboring gene microRNA 3661

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with S-phase kinase-associated protein 1 (SKP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC34403

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables F-box domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cullin family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables molecular function activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin ligase complex scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Cul7-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IC
    Inferred by Curator
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    S-phase kinase-associated protein 1
    Names
    OCP-2
    RNA polymerase II elongation factor-like protein OCP2
    SIII
    cyclin A/CDK2-associated p19
    cyclin-A/CDK2-associated protein p19
    organ of Corti protein 2
    organ of Corti protein II
    p19skp1
    transcription elongation factor B polypeptide 1-like
    NP_008861.2
    NP_733779.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006930.4NP_008861.2  S-phase kinase-associated protein 1 isoform a

      See identical proteins and their annotated locations for NP_008861.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript variant but encodes the shorter isoform (a).
      Source sequence(s)
      AI025746, AI028694, BC025673, BC065730, BI670085, BQ632052
      Consensus CDS
      CCDS4172.1
      UniProtKB/TrEMBL
      F8W8N3
      Related
      ENSP00000429472.1, ENST00000522552.5
      Conserved Domains (3) summary
      smart00512
      Location:1112
      Skp1; Found in Skp1 protein family
      COG5201
      Location:1153
      SKP1; SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]
      pfam01466
      Location:86153
      Skp1; Skp1 family, dimerization domain
    2. NM_170679.3NP_733779.1  S-phase kinase-associated protein 1 isoform b

      See identical proteins and their annotated locations for NP_733779.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) utilizes an alternate splice site in the 3' coding region, compared to variant 1. This results in a frameshift and slightly longer protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC011336, AI025746, AI028694, BC065730, BQ632052, Z47087
      Consensus CDS
      CCDS4171.1
      UniProtKB/Swiss-Prot
      D3DQ97, D3DQ98, P34991, P63208, Q8TAY2
      UniProtKB/TrEMBL
      E5RJR5
      Related
      ENSP00000231487.9, ENST00000353411.11
      Conserved Domains (2) summary
      cd18322
      Location:4127
      BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
      pfam01466
      Location:113160
      Skp1; Skp1 family, dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      134148935..134176950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      134672565..134700570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)