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    MRPL36 mitochondrial ribosomal protein L36 [ Homo sapiens (human) ]

    Gene ID: 64979, updated on 17-Jun-2024

    Summary

    Official Symbol
    MRPL36provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L36provided by HGNC
    Primary source
    HGNC:HGNC:14490
    See related
    Ensembl:ENSG00000171421 MIM:611842; AllianceGenome:HGNC:14490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPMJ; BRIP1; L36mt; bL36m; PRPL36; MRP-L36
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 2p. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 15.3), adrenal (RPKM 7.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MRPL36 in Genome Data Viewer
    Location:
    5p15.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (1798385..1801434, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (1713255..1716322, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (1798499..1799951, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374614 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:1708852-1709007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1708971-1709534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1709535-1710099 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1710100-1710663 Neighboring gene microRNA 4277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1745447-1745946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1751136-1751775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1768734-1769442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1769443-1770149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1771839-1772338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22311 Neighboring gene uncharacterized LOC101929003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22314 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:1801330-1802317 Neighboring gene NADH:ubiquinone oxidoreductase subunit S6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1815894-1816405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1817127-1817628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1817629-1818128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1827503-1828018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1828019-1828534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1831287-1831980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1831981-1832674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1833787-1834780 Neighboring gene VISTA enhancer hs2567 Neighboring gene eukaryotic translation initiation factor 3 subunit A Neighboring gene long intergenic non-protein coding RNA 2116

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    large ribosomal subunit protein bL36m
    Names
    39S ribosomal protein L36, mitochondrial
    BRCA1-interacting protein 1
    mitochondrial large ribosomal subunit protein bL36m
    putative BRCA1-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032479.4NP_115868.1  large ribosomal subunit protein bL36m

      See identical proteins and their annotated locations for NP_115868.1

      Status: REVIEWED

      Source sequence(s)
      BC104652, BG185418
      Consensus CDS
      CCDS3865.1
      UniProtKB/Swiss-Prot
      A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7
      Related
      ENSP00000423152.1, ENST00000505059.7
      Conserved Domains (1) summary
      pfam00444
      Location:66103
      Ribosomal_L36; Ribosomal protein L36

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      1798385..1801434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514080.3XP_011512382.1  large ribosomal subunit protein bL36m isoform X2

      Conserved Domains (1) summary
      pfam00444
      Location:81118
      Ribosomal_L36; Ribosomal protein L36
    2. XM_017009751.3XP_016865240.1  large ribosomal subunit protein bL36m isoform X3

      UniProtKB/Swiss-Prot
      A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7
      Conserved Domains (1) summary
      pfam00444
      Location:66103
      Ribosomal_L36; Ribosomal protein L36
    3. XM_017009750.2XP_016865239.1  large ribosomal subunit protein bL36m isoform X3

      UniProtKB/Swiss-Prot
      A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7
      Related
      ENSP00000372093.6, ENST00000382647.7
      Conserved Domains (1) summary
      pfam00444
      Location:66103
      Ribosomal_L36; Ribosomal protein L36
    4. XM_017009752.2XP_016865241.1  large ribosomal subunit protein bL36m isoform X3

      UniProtKB/Swiss-Prot
      A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7
      Related
      ENSP00000423399.1, ENST00000508987.1
      Conserved Domains (1) summary
      pfam00444
      Location:66103
      Ribosomal_L36; Ribosomal protein L36
    5. XM_011514079.2XP_011512381.1  large ribosomal subunit protein bL36m isoform X1

      Conserved Domains (1) summary
      pfam00444
      Location:132169
      Ribosomal_L36; Ribosomal protein L36

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      1713255..1716322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353182.1XP_054209157.1  large ribosomal subunit protein bL36m isoform X2

    2. XM_054353186.1XP_054209161.1  large ribosomal subunit protein bL36m isoform X3

      UniProtKB/Swiss-Prot
      A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7
    3. XM_054353184.1XP_054209159.1  large ribosomal subunit protein bL36m isoform X3

      UniProtKB/Swiss-Prot
      A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7
    4. XM_054353183.1XP_054209158.1  large ribosomal subunit protein bL36m isoform X3

      UniProtKB/Swiss-Prot
      A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7
    5. XM_054353185.1XP_054209160.1  large ribosomal subunit protein bL36m isoform X3

      UniProtKB/Swiss-Prot
      A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7
    6. XM_054353181.1XP_054209156.1  large ribosomal subunit protein bL36m isoform X1