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    SIPA1 signal-induced proliferation-associated 1 [ Homo sapiens (human) ]

    Gene ID: 6494, updated on 10-Dec-2024

    Summary

    Official Symbol
    SIPA1provided by HGNC
    Official Full Name
    signal-induced proliferation-associated 1provided by HGNC
    Primary source
    HGNC:HGNC:10885
    See related
    Ensembl:ENSG00000213445 MIM:602180; AllianceGenome:HGNC:10885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPA1
    Summary
    The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 30.1), lymph node (RPKM 17.9) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SIPA1 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65638101..65650912)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65632271..65645082)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65405572..65418383)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65380127-65381014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3545 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:65381903-65382789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3546 Neighboring gene pecanex 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65404393-65405183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4997 Neighboring gene microRNA 4690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4999 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65421552-65422052 Neighboring gene microRNA 4489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5000 Neighboring gene RELA proto-oncogene, NF-kB subunit Neighboring gene RELA divergent transcript Neighboring gene RNA, 7SL, cytoplasmic 309, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC17037, MGC102688

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    signal-induced proliferation-associated protein 1
    Names
    GTPase-activating protein Spa-1
    p130 SPA-1
    signal-induced proliferation-associated gene 1
    sipa-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006747.4NP_006738.3  signal-induced proliferation-associated protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AP001362
      Consensus CDS
      CCDS8108.1
      UniProtKB/Swiss-Prot
      O14518, O60484, O60618, Q2YD83, Q96FS4
      UniProtKB/TrEMBL
      F6RY50
      Related
      ENSP00000436269.1, ENST00000534313.6
      Conserved Domains (4) summary
      COG1196
      Location:9051027
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00595
      Location:687759
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:351532
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:9741030
      ZapB; Cell division protein ZapB
    2. NM_153253.30NP_694985.29  signal-induced proliferation-associated protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AP001362
      Consensus CDS
      CCDS8108.1
      UniProtKB/Swiss-Prot
      O14518, O60484, O60618, Q2YD83, Q96FS4
      UniProtKB/TrEMBL
      F6RY50
      Related
      ENSP00000377771.3, ENST00000394224.3
      Conserved Domains (4) summary
      COG1196
      Location:9051027
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00595
      Location:687759
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:351532
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:9741030
      ZapB; Cell division protein ZapB

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      65638101..65650912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427428.1XP_047283384.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O14518, O60484, O60618, Q2YD83, Q96FS4
      UniProtKB/TrEMBL
      F6RY50
    2. XM_047427430.1XP_047283386.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O14518, O60484, O60618, Q2YD83, Q96FS4
      UniProtKB/TrEMBL
      F6RY50
    3. XM_047427429.1XP_047283385.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O14518, O60484, O60618, Q2YD83, Q96FS4
      UniProtKB/TrEMBL
      F6RY50
    4. XM_047427427.1XP_047283383.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O14518, O60484, O60618, Q2YD83, Q96FS4
      UniProtKB/TrEMBL
      F6RY50
    5. XM_047427431.1XP_047283387.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O14518, O60484, O60618, Q2YD83, Q96FS4
      UniProtKB/TrEMBL
      F6RY50
    6. XM_005274189.3XP_005274246.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O14518, O60484, O60618, Q2YD83, Q96FS4
      UniProtKB/TrEMBL
      F6RY50
      Related
      ENSP00000433686.1, ENST00000527525.5
      Conserved Domains (4) summary
      COG1196
      Location:9051027
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00595
      Location:687759
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:351532
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:9741030
      ZapB; Cell division protein ZapB
    7. XM_047427432.1XP_047283388.1  signal-induced proliferation-associated protein 1 isoform X2

    8. XM_047427434.1XP_047283390.1  signal-induced proliferation-associated protein 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      65632271..65645082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369662.1XP_054225637.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O14518, O60484, O60618, Q2YD83, Q96FS4
      UniProtKB/TrEMBL
      F6RY50
    2. XM_054369666.1XP_054225641.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O14518, O60484, O60618, Q2YD83, Q96FS4
      UniProtKB/TrEMBL
      F6RY50
    3. XM_054369663.1XP_054225638.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O14518, O60484, O60618, Q2YD83, Q96FS4
      UniProtKB/TrEMBL
      F6RY50
    4. XM_054369665.1XP_054225640.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O14518, O60484, O60618, Q2YD83, Q96FS4
      UniProtKB/TrEMBL
      F6RY50
    5. XM_054369664.1XP_054225639.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O14518, O60484, O60618, Q2YD83, Q96FS4
      UniProtKB/TrEMBL
      F6RY50
    6. XM_054369667.1XP_054225642.1  signal-induced proliferation-associated protein 1 isoform X2

    7. XM_054369668.1XP_054225643.1  signal-induced proliferation-associated protein 1 isoform X3