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    Lpin2 lipin 2 [ Mus musculus (house mouse) ]

    Gene ID: 64898, updated on 8-Jul-2021

    Summary

    Official Symbol
    Lpin2provided by MGI
    Official Full Name
    lipin 2provided by MGI
    Primary source
    MGI:MGI:1891341
    See related
    Ensembl:ENSMUSG00000024052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI481352; AW742896; 2610511G02Rik
    Expression
    Ubiquitous expression in lung adult (RPKM 8.0), liver E18 (RPKM 7.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lpin2 in Genome Data Viewer
    Location:
    17; 17 E1.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (71490527..71556813)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71183532..71249818)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (71533318..71599158)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53974 Neighboring gene myomesin 1 Neighboring gene elastin microfibril interfacer 2 Neighboring gene RIKEN cDNA 4930471L23 gene Neighboring gene ubiquitin specific peptidase 16 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphatidate phosphatase LPIN2
    NP_001158357.1
    NP_001344720.1
    NP_075020.2
    XP_006524849.1
    XP_006524851.1
    XP_030105837.1
    XP_030105838.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164885.1NP_001158357.1  phosphatidate phosphatase LPIN2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC126942, AC154218, AW489885
      Consensus CDS
      CCDS50177.1
      UniProtKB/TrEMBL
      E9PWN0
      Related
      ENSMUSP00000118610.2, ENSMUST00000126681.8
      Conserved Domains (3) summary
      pfam04571
      Location:39144
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:672897
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:504594
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    2. NM_001357791.1NP_001344720.1  phosphatidate phosphatase LPIN2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126942, AC154218, AW489885
      Consensus CDS
      CCDS28956.1
      Conserved Domains (3) summary
      pfam04571
      Location:1106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:634859
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:466556
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    3. NM_022882.4NP_075020.2  phosphatidate phosphatase LPIN2 isoform 2

      See identical proteins and their annotated locations for NP_075020.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC126942, AC154218, AW489885
      Consensus CDS
      CCDS28956.1
      UniProtKB/Swiss-Prot
      Q99PI5
      Related
      ENSMUSP00000119282.2, ENSMUST00000129635.8
      Conserved Domains (3) summary
      pfam04571
      Location:1106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:634859
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:466556
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      71490527..71556813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249977.1XP_030105837.1  phosphatidate phosphatase LPIN2 isoform X3

      Conserved Domains (3) summary
      pfam04571
      Location:164
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:602827
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:434524
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    2. XM_030249978.2XP_030105838.1  phosphatidate phosphatase LPIN2 isoform X4

      Conserved Domains (2) summary
      pfam08235
      Location:373598
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:205295
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    3. XM_006524786.4XP_006524849.1  phosphatidate phosphatase LPIN2 isoform X1

      Conserved Domains (3) summary
      pfam04571
      Location:39102
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:640865
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:472562
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    4. XM_006524788.4XP_006524851.1  phosphatidate phosphatase LPIN2 isoform X2

      See identical proteins and their annotated locations for XP_006524851.1

      UniProtKB/Swiss-Prot
      Q99PI5
      Conserved Domains (3) summary
      pfam04571
      Location:1106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:634859
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:466556
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
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