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    chico [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 64880, updated on 8-Oct-2018

    Summary

    Official Symbol
    chicoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024248
    Locus tag
    Dmel_CG5686
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0078940.1; anon-WO0078940.4; BcDNA.GH11263; BcDNA:GH11263; CG5686; chic; Chico; CHICO; dIRS; Dmel\CG5686; fs(2)4; fs(2)ry4; IRS; IRS/chico

    Genomic context

    See chico in Genome Data Viewer
    Location:
    31B1-31B1; 2-40 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10242512..10247078, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10242512..10247078, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene methuselah-like 15 Neighboring gene maternal expression at 31B Neighboring gene ncRNA Neighboring gene basket Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    SH2 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    insulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    insulin receptor binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    insulin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    insulin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    insulin-like growth factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol 3-kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol 3-kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan TAS
    Traceable Author Statement
    more info
    PubMed 
    entry into reproductive diapause IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ-line stem-cell niche homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth of a germarium-derived egg chamber IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    insulin-like growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male germ-line stem cell asymmetric division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of triglyceride catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell size TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of multicellular organism growth TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of organ growth TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    primary spermatocyte growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of activin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of tube length, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to anoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to starvation TAS
    Traceable Author Statement
    more info
    PubMed 
    vitellogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    chico
    Names
    CG5686-PA
    CG5686-PB
    CG5686-PC
    chico-PA
    chico-PB
    chico-PC
    flipper
    insulin receptor substrate
    insulin-like receptor substrate

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10242512..10247078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201843.2NP_001188772.1  chico, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188772.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XTN2
      UniProtKB/TrEMBL
      M9PCQ8
      Related
      FBpp0292907, FBtr0303904
      Conserved Domains (3) summary
      cd01204
      Location:122235
      PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
      cd01257
      Location:7112
      PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
      pfam00169
      Location:25104
      PH; PH domain
    2. NM_164899.3NP_723540.1  chico, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723540.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XTN2
      UniProtKB/TrEMBL
      M9PCQ8
      Related
      FBpp0079677, FBtr0080088
      Conserved Domains (3) summary
      cd01204
      Location:122235
      PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
      cd01257
      Location:7112
      PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
      pfam00169
      Location:25104
      PH; PH domain
    3. NM_001273387.1NP_001260316.1  chico, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260316.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XTN2
      UniProtKB/TrEMBL
      M9PCQ8
      Related
      FBpp0305604, FBtr0333412
      Conserved Domains (3) summary
      cd01204
      Location:122235
      PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
      cd01257
      Location:7112
      PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
      pfam00169
      Location:25104
      PH; PH domain
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