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    CFAP68 cilia and flagella associated protein 68 [ Homo sapiens (human) ]

    Gene ID: 64776, updated on 11-Apr-2024

    Summary

    Official Symbol
    CFAP68provided by HGNC
    Official Full Name
    cilia and flagella associated protein 68provided by HGNC
    Primary source
    HGNC:HGNC:1163
    See related
    Ensembl:ENSG00000137720 AllianceGenome:HGNC:1163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C11orf1
    Summary
    Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 18.8), kidney (RPKM 14.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    11q23.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (111879541..111885975)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (111889784..111896218)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111750265..111756699)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3902 Neighboring gene G protein subunit gamma 5 pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:111749557-111750176 Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene ribosomal protein L37a pseudogene 8 Neighboring gene HSPB2-C11orf52 readthrough (NMD candidate) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111784209-111784862 Neighboring gene crystallin alpha B Neighboring gene heat shock protein family B (small) member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23499

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in axonemal A tubule inner sheath IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    cilia- and flagella-associated protein 68
    Names
    UPF0686 protein C11orf1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330371.2NP_001317300.1  cilia- and flagella-associated protein 68 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AJ250229, AP001781, BM828345
      Consensus CDS
      CCDS81625.1
      UniProtKB/TrEMBL
      E9PS93
      Related
      ENSP00000435864.1, ENST00000530214.5
    2. NM_022761.3NP_073598.1  cilia- and flagella-associated protein 68 isoform 1

      See identical proteins and their annotated locations for NP_073598.1

      Status: VALIDATED

      Source sequence(s)
      AP001781
      Consensus CDS
      CCDS8350.1
      UniProtKB/Swiss-Prot
      Q6I9X7, Q9H5F2, Q9NQC6
      Related
      ENSP00000260276.3, ENST00000260276.8
      Conserved Domains (1) summary
      pfam06608
      Location:2149
      DUF1143; Protein of unknown function (DUF1143)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      111879541..111885975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542957.4XP_011541259.1  cilia- and flagella-associated protein 68 isoform X1

      UniProtKB/TrEMBL
      E9PMC1
      Related
      ENSP00000432128.1, ENST00000530799.5
      Conserved Domains (1) summary
      pfam06608
      Location:32165
      DUF1143; Protein of unknown function (DUF1143)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      111889784..111896218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369646.1XP_054225621.1  cilia- and flagella-associated protein 68 isoform X1