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    URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase [ Homo sapiens (human) ]

    Gene ID: 646625, updated on 5-Mar-2024

    Summary

    Official Symbol
    URADprovided by HGNC
    Official Full Name
    ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylaseprovided by HGNC
    Primary source
    HGNC:HGNC:17785
    See related
    Ensembl:ENSG00000183463 MIM:615804; AllianceGenome:HGNC:17785
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRHOXNB
    Summary
    Predicted to enable carboxy-lyase activity. Predicted to be involved in purine-containing compound catabolic process. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon (RPKM 3.8), small intestine (RPKM 0.9) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See URAD in Genome Data Viewer
    Location:
    13q12.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (27977717..27988693, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (27199102..27210083, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (28551854..28562830, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5205 Neighboring gene long intergenic non-protein coding RNA 543 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr13:28539919-28540610 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:28540611-28541302 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:28542687-28543378 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr13:28545455-28546102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:28546103-28546749 Neighboring gene caudal type homeobox 2 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr13:28552766-28553299 Neighboring gene uncharacterized LOC105370132 Neighboring gene RNA, 7SL, cytoplasmic 272, pseudogene Neighboring gene fms related receptor tyrosine kinase 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:28596542-28597075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:28597076-28597608 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:28624211-28624978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:28625785-28626285 Neighboring gene katanin regulatory subunit B1 like 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carboxy-lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in allantoin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in urate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
    Names
    OHCU decarboxylase
    parahox cluster neighbor
    NP_001099047.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105577.2NP_001099047.1  putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

      See identical proteins and their annotated locations for NP_001099047.1

      Status: INFERRED

      Source sequence(s)
      AL591024
      Consensus CDS
      CCDS45020.1
      UniProtKB/Swiss-Prot
      A6NGE7
      Related
      ENSP00000333490.4, ENST00000332715.6
      Conserved Domains (1) summary
      pfam09349
      Location:10163
      OHCU_decarbox; OHCU decarboxylase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      27977717..27988693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      27199102..27210083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)