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    Ireb2 iron responsive element binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 64602, updated on 2-Oct-2018

    Summary

    Official Symbol
    Ireb2provided by MGI
    Official Full Name
    iron responsive element binding protein 2provided by MGI
    Primary source
    MGI:MGI:1928268
    See related
    Ensembl:ENSMUSG00000032293 Vega:OTTMUSG00000063245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Irp2; D9Ertd85e
    Expression
    Broad expression in CNS E11.5 (RPKM 14.9), CNS E14 (RPKM 13.7) and 23 other tissues See more
    Orthologs

    Genomic context

    See Ireb2 in Genome Data Viewer
    Location:
    9 B; 9 29.81 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (54863665..54912534)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (54711562..54760341)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene cellular retinoic acid binding protein I Neighboring gene RAB7, member RAS oncogene family, pseudogene 1 Neighboring gene hydroxylysine kinase 1 Neighboring gene cDNA sequence AY074887 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Iron Homeostasis, organism-specific biosystem (from WikiPathways)
      Iron Homeostasis, organism-specific biosystemIron is nessisary for all mammalian cells but is also toxic in excess. This pathway shows the regulation of iron between a cell and the blood stream.

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp564D1164

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    iron-responsive element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    iron-responsive element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    iron-responsive element binding ISO
    Inferred from Sequence Orthology
    more info
     
    iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    regulatory region RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulatory region RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation repressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    aging IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular iron ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to epidermal growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to iron(III) ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to iron(III) ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to manganese ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to manganese ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to mercaptoethanol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to mercaptoethanol ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxygen-glucose deprivation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to oxygen-glucose deprivation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to retinoic acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    citrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    erythrocyte homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    erythrocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intestinal absorption IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    iron ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    osteoclast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    post-embryonic development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protoporphyrinogen IX biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protoporphyrinogen IX biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to copper ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to hypobaric hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to iron(II) ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to iron(III) ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to iron(III) ion ISO
    Inferred from Sequence Orthology
    more info
     
    response to kainic acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to retinoic acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    skeletal muscle atrophy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    iron-responsive element-binding protein 2
    Names
    IRE-BP 2
    iron regulatory protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022655.3NP_073146.2  iron-responsive element-binding protein 2

      See identical proteins and their annotated locations for NP_073146.2

      Status: VALIDATED

      Source sequence(s)
      AC161264, CJ093933, CK636500, CN534597, CN664620, CO431396, CV558274
      Consensus CDS
      CCDS23196.1
      UniProtKB/Swiss-Prot
      Q811J3
      Related
      ENSMUSP00000034843.7, OTTMUSP00000079676, ENSMUST00000034843.8, OTTMUST00000154042
      Conserved Domains (3) summary
      cd01586
      Location:85641
      AcnA_IRP; Aconitase A catalytic domain
      cd01580
      Location:745913
      AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...
      PTZ00092
      Location:3961
      PTZ00092; aconitate hydratase-like protein; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      54863665..54912534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511335.3XP_006511398.1  iron-responsive element-binding protein 2 isoform X1

      Conserved Domains (1) summary
      cd01586
      Location:85641
      AcnA_IRP; Aconitase A catalytic domain
    2. XM_017313500.1XP_017168989.1  iron-responsive element-binding protein 2 isoform X3

    3. XM_017313499.1XP_017168988.1  iron-responsive element-binding protein 2 isoform X2

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