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    Ireb2 iron responsive element binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 64602, updated on 5-Jul-2021

    Summary

    Official Symbol
    Ireb2provided by MGI
    Official Full Name
    iron responsive element binding protein 2provided by MGI
    Primary source
    MGI:MGI:1928268
    See related
    Ensembl:ENSMUSG00000032293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I; Irp2; D9Ertd85; D9Ertd85e
    Expression
    Broad expression in CNS E11.5 (RPKM 14.9), CNS E14 (RPKM 13.7) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ireb2 in Genome Data Viewer
    Location:
    9 B; 9 29.81 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54769942..54819818)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54862658..54912534)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (54711562..54760341)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cellular retinoic acid binding protein I Neighboring gene RAB7, member RAS oncogene family, pseudogene 1 Neighboring gene hydroxylysine kinase 1 Neighboring gene cDNA sequence AY074887 Neighboring gene proteasome subunit alpha 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp564D1164

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables iron-responsive element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables iron-responsive element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables iron-responsive element binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables regulatory region RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation repressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular iron ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to iron(III) ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to manganese ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to mercaptoethanol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxygen-glucose deprivation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in citrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intestinal absorption IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within iron ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within osteoclast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to iron(III) ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    iron-responsive element-binding protein 2
    Names
    IRE-BP 2
    iron regulatory protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022655.3NP_073146.2  iron-responsive element-binding protein 2

      See identical proteins and their annotated locations for NP_073146.2

      Status: VALIDATED

      Source sequence(s)
      AC161264, CJ093933, CK636500, CN534597, CN664620, CO431396, CV558274
      Consensus CDS
      CCDS23196.1
      UniProtKB/Swiss-Prot
      Q811J3
      Related
      ENSMUSP00000034843.8, ENSMUST00000034843.9
      Conserved Domains (3) summary
      cd01586
      Location:85641
      AcnA_IRP; Aconitase A catalytic domain
      cd01580
      Location:745913
      AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...
      PTZ00092
      Location:3961
      PTZ00092; aconitate hydratase-like protein; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      54769942..54819818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155171.1XP_036011064.1  iron-responsive element-binding protein 2 isoform X2

      Conserved Domains (1) summary
      PTZ00092
      Location:3710
      PTZ00092; aconitate hydratase-like protein; Provisional
    2. XM_006511335.4XP_006511398.1  iron-responsive element-binding protein 2 isoform X1

      Conserved Domains (1) summary
      PTZ00092
      Location:3691
      PTZ00092; aconitate hydratase-like protein; Provisional
    3. XM_017313500.2XP_017168989.1  iron-responsive element-binding protein 2 isoform X3

      Conserved Domains (1) summary
      PTZ00092
      Location:3727
      PTZ00092; aconitate hydratase-like protein; Provisional
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