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    Fcamr Fc receptor, IgA, IgM, high affinity [ Mus musculus (house mouse) ]

    Gene ID: 64435, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fcamrprovided by MGI
    Official Full Name
    Fc receptor, IgA, IgM, high affinityprovided by MGI
    Primary source
    MGI:MGI:1927803
    See related
    Ensembl:ENSMUSG00000026415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in spleen adult (RPKM 2.6), kidney adult (RPKM 1.8) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Fcamr in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130712444..130753641)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130784706..130825903)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (132697479..132711317)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AA986860 Neighboring gene predicted gene 28857 Neighboring gene predicted gene 28856 Neighboring gene predicted gene 15848 Neighboring gene polymeric immunoglobulin receptor Neighboring gene Fc fragment of IgM receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Homology

    Clone Names

    • MGC129330, MGC129331

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables IgA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables IgM binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
    Names
    Fc IgA/IgM receptor
    Fca/m receptor
    fc alpha/mu receptor
    mFcamR

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170632.1NP_001164103.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC139231, FJ011703
      Consensus CDS
      CCDS48353.1
      UniProtKB/Swiss-Prot
      Q2TB54
      Related
      ENSMUSP00000108096.3, ENSMUST00000112477.9
      Conserved Domains (2) summary
      cd05716
      Location:145245
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:143246
      IG_like; Immunoglobulin like
    2. NM_144960.2NP_659209.2  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_659209.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AB048834, BC110549, BC110550
      Consensus CDS
      CCDS15259.1
      UniProtKB/Swiss-Prot
      Q2TB54
      Related
      ENSMUSP00000027670.4, ENSMUST00000027670.4
      Conserved Domains (1) summary
      cd05716
      Location:89189
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      130712444..130753641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529787.5XP_006529850.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X2

      See identical proteins and their annotated locations for XP_006529850.1

      UniProtKB/Swiss-Prot
      Q2TB54
      Conserved Domains (1) summary
      cd05716
      Location:89189
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
    2. XM_017321925.3XP_017177414.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X2

      UniProtKB/Swiss-Prot
      Q2TB54
      Conserved Domains (1) summary
      cd05716
      Location:89189
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
    3. XM_017321923.3XP_017177412.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

      Conserved Domains (1) summary
      cd05716
      Location:139239
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
    4. XM_017321921.2XP_017177410.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

      Conserved Domains (1) summary
      cd05716
      Location:139239
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
    5. XM_017321922.2XP_017177411.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

      Conserved Domains (1) summary
      cd05716
      Location:139239
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
    6. XM_017321924.2XP_017177413.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

      Conserved Domains (1) summary
      cd05716
      Location:139239
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
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