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    INSYN2A inhibitory synaptic factor 2A [ Homo sapiens (human) ]

    Gene ID: 642938, updated on 5-Mar-2024

    Summary

    Official Symbol
    INSYN2Aprovided by HGNC
    Official Full Name
    inhibitory synaptic factor 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:33859
    See related
    Ensembl:ENSG00000188916 MIM:617129; AllianceGenome:HGNC:33859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INSYN2; FAM196A; C10orf141
    Summary
    Predicted to be involved in inhibitory postsynaptic potential. Predicted to be active in postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    10q26.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (127135430..127196591, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (128029007..128090188, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (128933694..128994855, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:128798279-128799478 Neighboring gene uncharacterized LOC107984059 Neighboring gene uncharacterized LOC105378552 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:128868600-128869799 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:128936224-128937423 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:128946487-128947686 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:129078632-129079159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4196 Neighboring gene uncharacterized LOC105378551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129190073-129190574 Neighboring gene uncharacterized LOC124902524

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ45557

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in inhibitory postsynaptic potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inhibitory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    inhibitory synaptic factor 2A
    Names
    family with sequence similarity 196 member A
    inhibitory synaptic protein 2
    protein FAM196A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039762.3NP_001034851.1  inhibitory synaptic factor 2A

      See identical proteins and their annotated locations for NP_001034851.1

      Status: VALIDATED

      Source sequence(s)
      AK127465, AL390920, BC137112
      Consensus CDS
      CCDS31312.1
      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
      Related
      ENSP00000429763.1, ENST00000522781.6
      Conserved Domains (1) summary
      pfam15265
      Location:1479
      FAM196; FAM196 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      127135430..127196591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005252694.5XP_005252751.1  inhibitory synaptic factor 2A isoform X1

      See identical proteins and their annotated locations for XP_005252751.1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
      Conserved Domains (1) summary
      pfam15265
      Location:1479
      FAM196; FAM196 family
    2. XM_017016539.3XP_016872028.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
      Conserved Domains (1) summary
      pfam15265
      Location:1479
      FAM196; FAM196 family
    3. XM_047425638.1XP_047281594.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
    4. XM_047425636.1XP_047281592.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
    5. XM_047425637.1XP_047281593.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
    6. XM_017016537.3XP_016872026.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
      Conserved Domains (1) summary
      pfam15265
      Location:1479
      FAM196; FAM196 family
    7. XM_017016541.2XP_016872030.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
      Conserved Domains (1) summary
      pfam15265
      Location:1479
      FAM196; FAM196 family
    8. XM_047425639.1XP_047281595.1  inhibitory synaptic factor 2A isoform X2

      Related
      ENSP00000428730.1, ENST00000424811.2
    9. XM_047425634.1XP_047281590.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
    10. XM_047425635.1XP_047281591.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
    11. XM_017016543.2XP_016872032.1  inhibitory synaptic factor 2A isoform X3

      Conserved Domains (1) summary
      pfam15265
      Location:1395
      FAM196; FAM196 family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      128029007..128090188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366566.1XP_054222541.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
    2. XM_054366565.1XP_054222540.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
    3. XM_054366564.1XP_054222539.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
    4. XM_054366563.1XP_054222538.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2
    5. XM_054366567.1XP_054222542.1  inhibitory synaptic factor 2A isoform X2

    6. XM_054366562.1XP_054222537.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RNT4, B7ZME7, Q6ZSG2