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    SRSF2 serine and arginine rich splicing factor 2 [ Homo sapiens (human) ]

    Gene ID: 6427, updated on 7-Sep-2023

    Summary

    Official Symbol
    SRSF2provided by HGNC
    Official Full Name
    serine and arginine rich splicing factor 2provided by HGNC
    Primary source
    HGNC:HGNC:10783
    See related
    Ensembl:ENSG00000161547 MIM:600813; AllianceGenome:HGNC:10783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SC35; PR264; SC-35; SFRS2; SFRS2A; SRp30b
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in bone marrow (RPKM 91.7), lymph node (RPKM 69.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SRSF2 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (76734115..76737411, complement)
    RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (77631102..77634398, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74730197..74733493, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene matrix remodeling associated 7 Neighboring gene RNY4 pseudogene 36 Neighboring gene jumonji domain containing 6, arginine demethylase and lysine hydroxylase Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74722561-74723190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74723821-74724449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74725107-74725737 Neighboring gene methyltransferase 23, arginine Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74732487-74733112 Neighboring gene microRNA 636 Neighboring gene major facilitator superfamily domain containing 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74751679-74752180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74752181-74752680 Neighboring gene RNA, U6 small nuclear 97, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:74800558-74801081 Neighboring gene long intergenic non-protein coding RNA 2080

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of serine/arginine-rich splicing factor 2 (SRSF2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev SC-35 has been shown to inhibit Rev function in a dose-dependent fashion PubMed
    rev The splicing inhibitory function of Rev has been associated with Rev localization to subnuclear compartments containing the splicing factor SC-35 PubMed
    Tat tat HIV-1 Tat increases phosphorylation of SRSF2 in human SH-SY5Y (neuroblastoma cell line) PubMed
    tat SRSF2 and SRSF6 cooperatively activate HIV-1 Tat-specific 3'ss A3 site, either through two separate required mechanisms or by stabilizing each other on their respective target sequences PubMed
    tat Serine/arginine-rich splicing factor 2 (SRSF2) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    tat SRSF2 (serine/arginine-rich splicing factor 2) inhibits HIV-1 Tat-mediated transactivation activity in HEK293 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mRNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    NOT located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/arginine-rich splicing factor 2
    Names
    SR splicing factor 2
    splicing component, 35 kDa
    splicing factor SC35
    splicing factor, arginine/serine-rich 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032905.1 RefSeqGene

      Range
      5001..8297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_640

    mRNA and Protein(s)

    1. NM_001195427.2NP_001182356.1  serine/arginine-rich splicing factor 2

      See identical proteins and their annotated locations for NP_001182356.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC005837
      Consensus CDS
      CCDS11749.1
      UniProtKB/Swiss-Prot
      B3KWD5, B4DN89, H0YG49, Q01130
      UniProtKB/TrEMBL
      A0A024R8U5, Q53FN0
      Related
      ENSP00000353089.5, ENST00000359995.10
      Conserved Domains (1) summary
      cd12311
      Location:1688
      RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins
    2. NM_003016.4NP_003007.2  serine/arginine-rich splicing factor 2

      See identical proteins and their annotated locations for NP_003007.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC005837, BC070086, DA513281, DC361254
      Consensus CDS
      CCDS11749.1
      UniProtKB/Swiss-Prot
      B3KWD5, B4DN89, H0YG49, Q01130
      UniProtKB/TrEMBL
      A0A024R8U5, Q53FN0
      Related
      ENSP00000376276.2, ENST00000392485.2
      Conserved Domains (1) summary
      cd12311
      Location:1688
      RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

    RNA

    1. NR_036608.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Translation of this transcript would result in it being a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought that this transcript encodes a protein.
      Source sequence(s)
      AC005837

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      76734115..76737411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_429913.5 RNA Sequence

    2. XR_429914.5 RNA Sequence

    3. XR_002958055.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      77631102..77634398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008484875.1 RNA Sequence

    2. XR_008484876.1 RNA Sequence

    3. XR_008484877.1 RNA Sequence