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    FAM110C family with sequence similarity 110 member C [ Homo sapiens (human) ]

    Gene ID: 642273, updated on 3-Apr-2024

    Summary

    Official Symbol
    FAM110Cprovided by HGNC
    Official Full Name
    family with sequence similarity 110 member Cprovided by HGNC
    Primary source
    HGNC:HGNC:33340
    See related
    Ensembl:ENSG00000184731 MIM:611395; AllianceGenome:HGNC:33340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables alpha-tubulin binding activity. Involved in positive regulation of cell migration; positive regulation of protein kinase B signaling; and regulation of cell projection assembly. Located in cell cortex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in esophagus (RPKM 9.1), colon (RPKM 5.4) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    2p25.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (38814..46505, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (32180..40449, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (38814..46505, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:67739-68240 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:150593-151572 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:151573-152550 Neighboring gene uncharacterized LOC105373324 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:162049-163248 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:197602-198801 Neighboring gene SH3 and SYLF domain containing 1 Neighboring gene MPRA-validated peak3578 silencer Neighboring gene MPRA-validated peak3579 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11099

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Whole genome association scan for genetic polymorphisms influencing information processing speed.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077710.3NP_001071178.2  protein FAM110C

      See identical proteins and their annotated locations for NP_001071178.2

      Status: VALIDATED

      Source sequence(s)
      AC097643
      Consensus CDS
      CCDS42645.1
      UniProtKB/Swiss-Prot
      Q1W6H9
      UniProtKB/TrEMBL
      B4DYQ4
      Related
      ENSP00000328347.4, ENST00000327669.5
      Conserved Domains (2) summary
      pfam14160
      Location:194303
      FAM110_C; Centrosome-associated C terminus
      pfam14161
      Location:1449
      FAM110_N; Centrosome-associated N terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      38814..46505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510372.3XP_011508674.1  protein FAM110C isoform X3

      See identical proteins and their annotated locations for XP_011508674.1

      UniProtKB/TrEMBL
      B4DYQ4
      Conserved Domains (2) summary
      pfam14160
      Location:194303
      FAM110_C; Centrosome-associated C terminus
      pfam14161
      Location:1449
      FAM110_N; Centrosome-associated N terminus
    2. XM_017004690.2XP_016860179.1  protein FAM110C isoform X1

      UniProtKB/TrEMBL
      B4DYQ4
    3. XM_017004692.2XP_016860181.1  protein FAM110C isoform X2

      UniProtKB/TrEMBL
      B4DYQ4

    RNA

    1. XR_001738890.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      32180..40449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343348.1XP_054199323.1  protein FAM110C isoform X4

    2. XM_054343349.1XP_054199324.1  protein FAM110C isoform X4

    3. XM_054343347.1XP_054199322.1  protein FAM110C isoform X3

    4. XM_054343344.1XP_054199319.1  protein FAM110C isoform X1

    5. XM_054343345.1XP_054199320.1  protein FAM110C isoform X1

    6. XM_054343346.1XP_054199321.1  protein FAM110C isoform X2

    RNA

    1. XR_008486486.1 RNA Sequence