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    SELENOW selenoprotein W [ Homo sapiens (human) ]

    Gene ID: 6415, updated on 17-Jun-2024

    Summary

    Official Symbol
    SELENOWprovided by HGNC
    Official Full Name
    selenoprotein Wprovided by HGNC
    Primary source
    HGNC:HGNC:10752
    See related
    Ensembl:ENSG00000178980 MIM:603235; AllianceGenome:HGNC:10752
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    selW; SEPW1
    Summary
    This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A retroprocessed pseudogene of this locus has been identified on chromosome 1. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in heart (RPKM 246.5), brain (RPKM 150.5) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SELENOW in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (47778703..47784682)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (50609522..50615500)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48281960..48287939)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NOP53 ribosome biogenesis factor Neighboring gene NOP53 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 23 Neighboring gene Sharpr-MPRA regulatory region 15394 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48270445-48270705 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10869 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48284325-48284910 Neighboring gene ribosomal protein L23a pseudogene 80 Neighboring gene tetrapeptide repeat homeobox 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to selenium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    selenoprotein W
    Names
    selenoprotein W, 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003009.4NP_003000.1  selenoprotein W

      See identical proteins and their annotated locations for NP_003000.1

      Status: REVIEWED

      Source sequence(s)
      AC008745, BC039597, CR991097
      Consensus CDS
      CCDS59402.1
      UniProtKB/Swiss-Prot
      A8MRR7, O15532, O19096, P63302, Q86TI9, Q96KM5
      Related
      ENSP00000473185.1, ENST00000601048.6
      Conserved Domains (1) summary
      TIGR02174
      Location:578
      CXXU_selWTH; selT/selW/selH selenoprotein domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      47778703..47784682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      50609522..50615500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)