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    NOD2 nucleotide binding oligomerization domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 64127, updated on 8-Jul-2021

    Summary

    Official Symbol
    NOD2provided by HGNC
    Official Full Name
    nucleotide binding oligomerization domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:5331
    See related
    Ensembl:ENSG00000167207 MIM:605956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD; ACUG; BLAU; IBD1; YAOS; BLAUS; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1
    Summary
    This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
    Expression
    Broad expression in bone marrow (RPKM 3.3), appendix (RPKM 2.5) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NOD2 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (50693587..50733077)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50727517..50766986)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NKD inhibitor of WNT signaling pathway 1 Neighboring gene uncharacterized LOC101927272 Neighboring gene sorting nexin 20 Neighboring gene CYLD antisense RNA 1 Neighboring gene microRNA 3181 Neighboring gene CYLD lysine 63 deubiquitinase Neighboring gene uncharacterized LOC105371251 Neighboring gene long intergenic non-protein coding RNA 2168

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
    GeneReviews: Not available
    A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
    GeneReviews: Not available
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    GeneReviews: Not available
    Blau syndrome
    MedGen: C5201146 OMIM: 186580 GeneReviews: Not available
    Compare labs
    Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
    GeneReviews: Not available
    Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
    GeneReviews: Not available
    Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
    GeneReviews: Not available
    Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
    GeneReviews: Not available
    Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
    GeneReviews: Not available
    Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
    GeneReviews: Not available
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    GeneReviews: Not available
    Genomewide association study of leprosy.
    GeneReviews: Not available
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    GeneReviews: Not available
    Inflammatory bowel disease 1
    MedGen: C0678202 OMIM: 266600 GeneReviews: Not available
    Compare labs
    Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.
    GeneReviews: Not available
    Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.
    GeneReviews: Not available
    Systematic association mapping identifies NELL1 as a novel IBD disease gene.
    GeneReviews: Not available
    Yao syndrome
    MedGen: C4310620 OMIM: 617321 GeneReviews: Not available
    Compare labs

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates the gene expression of NOD2 in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables CARD domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables muramyl dipeptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pattern recognition receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to muramyl dipeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to muramyl dipeptide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to peptidoglycan IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in detection of bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in detection of biotic stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within detection of muramyl dipeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in detection of muramyl dipeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response in mucosa IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in maintenance of gastrointestinal epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of T cell mediated immunity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-18 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-2 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of macrophage apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of toll-like receptor 2 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pattern recognition receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of B cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokine production involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytokine production involved in inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of dendritic cell antigen processing and presentation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendritic cell cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gamma-delta T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-1 beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-10 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-17 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-8 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of monocyte chemotactic protein-1 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of nitric-oxide synthase biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of prostaglandin-E synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of prostaglandin-endoperoxide synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein K63-linked ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of type 2 immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of xenophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of inflammatory response IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to exogenous dsRNA IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to muramyl dipeptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to muramyl dipeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to muramyl dipeptide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in anchored component of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nucleotide-binding oligomerization domain-containing protein 2
    Names
    NLR family, CARD domain containing 2
    NOD-like receptor C2
    caspase recruitment domain family, member 15
    caspase recruitment domain protein 15
    caspase recruitment domain-containing protein 15
    inflammatory bowel disease protein 1
    nucleotide-binding oligomerization domain 2
    nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007508.1 RefSeqGene

      Range
      5001..40939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_177

    mRNA and Protein(s)

    1. NM_001293557.2NP_001280486.1  nucleotide-binding oligomerization domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001280486.1

      Status: REVIEWED

      Source sequence(s)
      AC007608, AC007728
      Consensus CDS
      CCDS86525.1
      UniProtKB/Swiss-Prot
      Q9HC29
      Conserved Domains (6) summary
      cd08788
      Location:107187
      CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2
      sd00033
      Location:793817
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:737764
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:266436
      NACHT; NACHT domain
      cl14633
      Location:792
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl29113
      Location:7401005
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. NM_001370466.1NP_001357395.1  nucleotide-binding oligomerization domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC007608, AC007728
      Related
      ENSP00000495993.1, ENST00000647318.2
      Conserved Domains (6) summary
      cd08788
      Location:107187
      CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2
      sd00033
      Location:793817
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:737764
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:266436
      NACHT; NACHT domain
      cl14633
      Location:792
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl29113
      Location:7401005
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. NM_022162.3NP_071445.1  nucleotide-binding oligomerization domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_071445.1

      Status: REVIEWED

      Source sequence(s)
      AC007608, AC007728
      Consensus CDS
      CCDS10746.1
      UniProtKB/Swiss-Prot
      Q9HC29
      Related
      ENSP00000300589.2, ENST00000300589.6
      Conserved Domains (7) summary
      COG4886
      Location:7951040
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:7671032
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08788
      Location:134214
      CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2
      sd00033
      Location:820844
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:764791
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:293463
      NACHT; NACHT domain
      cl14633
      Location:34119
      DD; Death Domain Superfamily of protein-protein interaction domains

    RNA

    1. NR_163434.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007608, AC007728
      Related
      ENST00000646677.1

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      50693587..50733077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023536.1XP_016879025.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X4

      Conserved Domains (4) summary
      cd00116
      Location:545810
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:598622
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:542569
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:71241
      NACHT; NACHT domain
    2. XM_017023537.1XP_016879026.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X4

      Conserved Domains (4) summary
      cd00116
      Location:545810
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:598622
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:542569
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:71241
      NACHT; NACHT domain
    3. XM_006721242.4XP_006721305.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X2

      Conserved Domains (7) summary
      COG4886
      Location:768985
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:753977
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08788
      Location:107187
      CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2
      sd00033
      Location:793817
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:737752
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:266436
      NACHT; NACHT domain
      cl14633
      Location:792
      DD; Death Domain Superfamily of protein-protein interaction domains
    4. XM_011523260.3XP_011521562.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X6

      See identical proteins and their annotated locations for XP_011521562.1

      UniProtKB/TrEMBL
      A0A286YF65
      Conserved Domains (3) summary
      cd08787
      Location:792
      CARD_NOD2_1_CARD15; Caspase activation and recruitment domain of NOD2, repeat 1
      cd08788
      Location:107187
      CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2
      pfam05729
      Location:266436
      NACHT; NACHT domain
    5. XM_006721243.4XP_006721306.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X5

      See identical proteins and their annotated locations for XP_006721306.1

      UniProtKB/TrEMBL
      A0A286YF65
      Related
      ENSP00000493088.1, ENST00000641284.1
      Conserved Domains (3) summary
      cd08787
      Location:792
      CARD_NOD2_1_CARD15; Caspase activation and recruitment domain of NOD2, repeat 1
      cd08788
      Location:107187
      CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2
      pfam05729
      Location:266436
      NACHT; NACHT domain
    6. XM_011523261.2XP_011521563.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X7

      See identical proteins and their annotated locations for XP_011521563.1

      UniProtKB/TrEMBL
      A0A286YF65
      Conserved Domains (3) summary
      cd08787
      Location:792
      CARD_NOD2_1_CARD15; Caspase activation and recruitment domain of NOD2, repeat 1
      cd08788
      Location:107187
      CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2
      pfam05729
      Location:266436
      NACHT; NACHT domain
    7. XM_011523259.2XP_011521561.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X4

      Conserved Domains (4) summary
      cd00116
      Location:545810
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:598622
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:542569
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:71241
      NACHT; NACHT domain
    8. XM_017023538.1XP_016879027.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X4

      Conserved Domains (4) summary
      cd00116
      Location:545810
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:598622
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:542569
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:71241
      NACHT; NACHT domain
    9. XM_017023535.1XP_016879024.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X3

    RNA

    1. XR_933387.2 RNA Sequence

    2. XR_429725.3 RNA Sequence

    3. XR_429726.3 RNA Sequence

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