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    RRAGC Ras related GTP binding C [ Homo sapiens (human) ]

    Gene ID: 64121, updated on 3-May-2024

    Summary

    Official Symbol
    RRAGCprovided by HGNC
    Official Full Name
    Ras related GTP binding Cprovided by HGNC
    Primary source
    HGNC:HGNC:19902
    See related
    Ensembl:ENSG00000116954 MIM:608267; AllianceGenome:HGNC:19902
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GTR2; RAGC; LNGOS; LNGODS; TIB929
    Summary
    This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
    Expression
    Ubiquitous expression in fat (RPKM 23.8), placenta (RPKM 15.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RRAGC in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (38838198..38859772, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (38705423..38727008, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (39303870..39325444, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378658 Neighboring gene CRISPRi-validated cis-regulatory element chr1.5052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38995999-38996641 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:39021300-39022499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39025118-39025733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39034058-39034665 Neighboring gene MPRA-validated peak186 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:39065535-39066150 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:39066151-39066766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39073721-39074510 Neighboring gene uncharacterized LOC105378660 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:39165731-39165950 Neighboring gene VISTA enhancer hs1031 Neighboring gene HSPA5 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39206875-39207549 Neighboring gene Sharpr-MPRA regulatory region 12321 Neighboring gene NANOG hESC enhancer GRCh37_chr1:39212546-39213129 Neighboring gene VISTA enhancer hs1139 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:39253877-39254442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39281537-39282038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39282039-39282538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 688 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:39285036-39285203 Neighboring gene Sharpr-MPRA regulatory region 3933 Neighboring gene GJA9-MYCBP readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:39338054-39338576 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:39345299-39345483 Neighboring gene RRAGC divergent transcript Neighboring gene MYC binding protein Neighboring gene gap junction protein alpha 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: MYCBP

    Clone Names

    • FLJ13311

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GDP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-membrane adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in RNA splicing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to amino acid starvation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to amino acid stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of TOR signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to amino acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in small GTPase-mediated signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of FNIP-folliculin RagC/D GAP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Gtr1-Gtr2 GTPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ras-related GTP-binding protein C
    Names
    GTPase-interacting protein 2
    Rag C protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271851.2NP_001258780.1  ras-related GTP-binding protein C isoform 2

      See identical proteins and their annotated locations for NP_001258780.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AK298573, AK298788, AW327252, BC016668, BI461665, BQ003663, CB132041, CX761032, ES308561, HY202961, HY264464
      UniProtKB/TrEMBL
      B4DQG4
      Conserved Domains (1) summary
      cd11385
      Location:63203
      RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
    2. NM_022157.4NP_071440.1  ras-related GTP-binding protein C isoform 1

      See identical proteins and their annotated locations for NP_071440.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK315791, BC016668, BI461665, BQ003663, CA449149, CB132041, CX761032, HY202961, HY264464
      Consensus CDS
      CCDS430.1
      UniProtKB/Swiss-Prot
      Q9H202, Q9H8Q8, Q9HB90
      UniProtKB/TrEMBL
      B4DQG4
      Related
      ENSP00000362092.3, ENST00000373001.4
      Conserved Domains (1) summary
      cd11385
      Location:63237
      RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      38838198..38859772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      38705423..38727008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)