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    GOLPH3 golgi phosphoprotein 3 [ Homo sapiens (human) ]

    Gene ID: 64083, updated on 7-Apr-2024

    Summary

    Official Symbol
    GOLPH3provided by HGNC
    Official Full Name
    golgi phosphoprotein 3provided by HGNC
    Primary source
    HGNC:HGNC:15452
    See related
    Ensembl:ENSG00000113384 MIM:612207; AllianceGenome:HGNC:15452
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GOPP1; GPP34; MIDAS; Vps74
    Summary
    The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in gall bladder (RPKM 38.1), prostate (RPKM 32.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GOLPH3 in Genome Data Viewer
    Location:
    5p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (32124716..32174319, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (32238327..32287926, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (32124822..32174425, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 2 Neighboring gene NANOG hESC enhancer GRCh37_chr5:31965348-31965849 Neighboring gene microRNA 4279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:32016671-32017172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:32017173-32017672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:32027139-32027640 Neighboring gene NANOG hESC enhancer GRCh37_chr5:32041483-32042015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:32092735-32093236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:32093237-32093736 Neighboring gene uncharacterized LOC105374711 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:32097810-32099009 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:32125750-32126949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15954 Neighboring gene Sharpr-MPRA regulatory region 2864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:32231740-32232285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:32232286-32232830 Neighboring gene MTMR12 eExon liver enhancer Neighboring gene RNA, U6 small nuclear 1079, pseudogene Neighboring gene ribosomal protein L27 pseudogene 10 Neighboring gene myotubularin related protein 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of golgi phosphoprotein 3 (GOLPH3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with golgi phosphoprotein 3 (GOLPH3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90675

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatidylinositol-4-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Golgi ribbon formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Golgi vesicle budding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi vesicle budding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in asymmetric Golgi ribbon formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion molecule production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to rapamycin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycoprotein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leukocyte tethering or rolling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein retention in Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitochondrion organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in Golgi cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi cisterna IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Golgi phosphoprotein 3
    Names
    coat protein GPP34
    coat-protein
    golgi peripheral membrane protein 1, 34 kDa
    golgi protein
    golgi-associated protein
    mitochondrial DNA absence factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022130.4NP_071413.1  Golgi phosphoprotein 3

      See identical proteins and their annotated locations for NP_071413.1

      Status: REVIEWED

      Source sequence(s)
      AC025178, AC025181
      Consensus CDS
      CCDS3896.1
      UniProtKB/Swiss-Prot
      Q9H4A6, Q9UIW5
      UniProtKB/TrEMBL
      B4DWL6
      Related
      ENSP00000265070.6, ENST00000265070.7
      Conserved Domains (1) summary
      pfam05719
      Location:62271
      GPP34; Golgi phosphoprotein 3 (GPP34)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      32124716..32174319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      32238327..32287926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)