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    MMP27 matrix metallopeptidase 27 [ Homo sapiens (human) ]

    Gene ID: 64066, updated on 5-Mar-2024

    Summary

    Official Symbol
    MMP27provided by HGNC
    Official Full Name
    matrix metallopeptidase 27provided by HGNC
    Primary source
    HGNC:HGNC:14250
    See related
    Ensembl:ENSG00000137675 MIM:618101; AllianceGenome:HGNC:14250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MMP-27
    Summary
    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MMP27 in Genome Data Viewer
    Location:
    11q22.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (102691487..102705769, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (102693656..102707936, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (102562218..102576500, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:102486041-102486542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:102486543-102487042 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18652 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18668 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18672 Neighboring gene MMP20 antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18676 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18677 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18685 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:102594892-102596091 Neighboring gene matrix metallopeptidase 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:102617370-102617934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:102617935-102618499 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:102623204-102624403 Neighboring gene sacsin molecular chaperone pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    matrix metalloproteinase-27
    Names
    matrix metalloprotease 27

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022122.3NP_071405.2  matrix metalloproteinase-27 precursor

      See identical proteins and their annotated locations for NP_071405.2

      Status: REVIEWED

      Source sequence(s)
      AP000647, AP000851, AY358752, BX102293
      Consensus CDS
      CCDS8319.1
      UniProtKB/Swiss-Prot
      Q6UWK6, Q9H306
      Related
      ENSP00000260229.4, ENST00000260229.5
      Conserved Domains (4) summary
      cd00094
      Location:276465
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:106261
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:106261
      Peptidase_M10; Matrixin
      pfam01471
      Location:2686
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      102691487..102705769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542950.4XP_011541252.1  matrix metalloproteinase-27 isoform X4

      Conserved Domains (3) summary
      cd00094
      Location:171360
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:9156
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:9156
      Peptidase_M10; Matrixin
    2. XM_011542948.3XP_011541250.1  matrix metalloproteinase-27 isoform X2

      Conserved Domains (4) summary
      cd00094
      Location:233422
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:106218
      Peptidase_M10; Matrixin
      pfam01471
      Location:2686
      PG_binding_1; Putative peptidoglycan binding domain
      cl00064
      Location:106218
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    3. XM_011542949.3XP_011541251.1  matrix metalloproteinase-27 isoform X3

      Conserved Domains (4) summary
      cd00094
      Location:222411
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:106207
      Peptidase_M10; Matrixin
      pfam01471
      Location:2686
      PG_binding_1; Putative peptidoglycan binding domain
      cl00064
      Location:106208
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    4. XM_017018120.2XP_016873609.1  matrix metalloproteinase-27 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      102693656..102707936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369629.1XP_054225604.1  matrix metalloproteinase-27 isoform X4

    2. XM_054369627.1XP_054225602.1  matrix metalloproteinase-27 isoform X2

    3. XM_054369628.1XP_054225603.1  matrix metalloproteinase-27 isoform X3

    4. XM_054369626.1XP_054225601.1  matrix metalloproteinase-27 isoform X1