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    SELE selectin E [ Homo sapiens (human) ]

    Gene ID: 6401, updated on 13-May-2024

    Summary

    Official Symbol
    SELEprovided by HGNC
    Official Full Name
    selectin Eprovided by HGNC
    Primary source
    HGNC:HGNC:10718
    See related
    Ensembl:ENSG00000007908 MIM:131210; AllianceGenome:HGNC:10718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ELAM; ESEL; CD62E; ELAM1; LECAM2; selectin-e
    Summary
    The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 16.5), urinary bladder (RPKM 15.5) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    1q24.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (169722640..169734079, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (169078428..169089853, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169691781..169703220, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985745 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:169636965-169637470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2078 Neighboring gene selectin L Neighboring gene uncharacterized LOC101928628 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169751147-169751648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2079 Neighboring gene FIGNL1 interacting regulator of recombination and mitosis Neighboring gene methyltransferase 18, RPL3 N3(tau)-histidine

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Over-expression of PPARalpha or PPARgamma attenuates Tat-induced up-regulation of inflammatory mediators, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, CCL2, and E-selectin PubMed
    tat HIV-1 Tat upregulates E-selectin (ELAM-1) in endothelial cells via an NF-kappa B-dependent mechanism PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oligosaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sialic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sialic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament-based process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of phospholipase C activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium-mediated signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in leukocyte cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in leukocyte migration involved in inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in leukocyte tethering or rolling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in leukocyte tethering or rolling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of leukocyte tethering or rolling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to interleukin-1 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to lipopolysaccharide TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to tumor necrosis factor TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    E-selectin
    Names
    CD62 antigen-like family member E
    ELAM-1
    endothelial adhesion molecule 1
    endothelial leukocyte adhesion molecule 1
    leukocyte endothelial cell adhesion molecule 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012124.1 RefSeqGene

      Range
      5001..16440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000450.2NP_000441.2  E-selectin precursor

      See identical proteins and their annotated locations for NP_000441.2

      Status: REVIEWED

      Source sequence(s)
      BC142711, DB209354
      Consensus CDS
      CCDS1283.1
      UniProtKB/Swiss-Prot
      A2RRD6, P16111, P16581
      UniProtKB/TrEMBL
      B2RAJ1
      Related
      ENSP00000331736.7, ENST00000333360.12
      Conserved Domains (3) summary
      cd03592
      Location:22140
      CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
      cd00054
      Location:148175
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl27761
      Location:333547
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      169722640..169734079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      169078428..169089853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)