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    Aqp9 aquaporin 9 [ Mus musculus (house mouse) ]

    Gene ID: 64008, updated on 18-Apr-2019

    Summary

    Official Symbol
    Aqp9provided by MGI
    Official Full Name
    aquaporin 9provided by MGI
    Primary source
    MGI:MGI:1891066
    See related
    Ensembl:ENSMUSG00000032204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AQP-9; AI266899; 1700020I22Rik
    Summary
    This gene encodes a member of the aquaglyceroporin subfamily of aquaporins. This protein transports water, glycerol, urea, purines and pyrimidines and plays a role in glycerol metabolism and osteoclast differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
    Expression
    Biased expression in liver adult (RPKM 30.0), liver E18 (RPKM 8.4) and 4 other tissues See more
    Orthologs

    Genomic context

    See Aqp9 in Genome Data Viewer
    Location:
    9; 9 D
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (71110659..71168085, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (70958468..71011096, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46119 Neighboring gene predicted gene, 46120 Neighboring gene predicted gene, 32714 Neighboring gene predicted gene, 32511 Neighboring gene predicted gene 3458

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    glycerol channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    purine nucleobase transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    pyrimidine nucleobase transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    urea channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    urea transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    water channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    water channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    amine transport ISO
    Inferred from Sequence Orthology
    more info
     
    canalicular bile acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    glycerol transport ISO
    Inferred from Sequence Orthology
    more info
     
    polyol transport ISO
    Inferred from Sequence Orthology
    more info
     
    purine nucleobase transport ISO
    Inferred from Sequence Orthology
    more info
     
    pyrimidine nucleobase transport ISO
    Inferred from Sequence Orthology
    more info
     
    response to mercury ion ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    urea transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    water transport ISO
    Inferred from Sequence Orthology
    more info
     
    water transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    aquaporin-9
    Names
    aquaglyceroporin-9

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271843.1NP_001258772.1  aquaporin-9 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AC098716
      Consensus CDS
      CCDS72270.1
      UniProtKB/TrEMBL
      D3YYD6
      Related
      ENSMUSP00000050127.5, ENSMUST00000060917.11
      Conserved Domains (1) summary
      cl00200
      Location:61292
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    2. NM_022026.3NP_071309.1  aquaporin-9 isoform 1

      See identical proteins and their annotated locations for NP_071309.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AI789806, AK050042
      Consensus CDS
      CCDS23325.1
      UniProtKB/Swiss-Prot
      Q9JJJ3
      UniProtKB/TrEMBL
      Q4FK77
      Related
      ENSMUSP00000074063.2, ENSMUST00000074465.8
      Conserved Domains (1) summary
      cl00200
      Location:24266
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    RNA

    1. NR_073483.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC098716
      Related
      ENSMUST00000144618.7

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      71110659..71168085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242783.1XP_011241085.1  aquaporin-9 isoform X1

      See identical proteins and their annotated locations for XP_011241085.1

      UniProtKB/Swiss-Prot
      Q9JJJ3
      UniProtKB/TrEMBL
      Q4FK77
      Conserved Domains (1) summary
      cl00200
      Location:24266
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    2. XM_006511331.2XP_006511394.1  aquaporin-9 isoform X1

      See identical proteins and their annotated locations for XP_006511394.1

      UniProtKB/Swiss-Prot
      Q9JJJ3
      UniProtKB/TrEMBL
      Q4FK77
      Related
      ENSMUSP00000109200.1, ENSMUST00000113570.7
      Conserved Domains (1) summary
      cl00200
      Location:24266
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    3. XM_011242782.2XP_011241084.1  aquaporin-9 isoform X1

      See identical proteins and their annotated locations for XP_011241084.1

      UniProtKB/Swiss-Prot
      Q9JJJ3
      UniProtKB/TrEMBL
      Q4FK77
      Conserved Domains (1) summary
      cl00200
      Location:24266
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    4. XM_006511332.3XP_006511395.1  aquaporin-9 isoform X1

      See identical proteins and their annotated locations for XP_006511395.1

      UniProtKB/Swiss-Prot
      Q9JJJ3
      UniProtKB/TrEMBL
      Q4FK77
      Conserved Domains (1) summary
      cl00200
      Location:24266
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
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