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    MYO1G myosin IG [ Homo sapiens (human) ]

    Gene ID: 64005, updated on 5-Mar-2024

    Summary

    Official Symbol
    MYO1Gprovided by HGNC
    Official Full Name
    myosin IGprovided by HGNC
    Primary source
    HGNC:HGNC:13880
    See related
    Ensembl:ENSG00000136286 MIM:600642; AllianceGenome:HGNC:13880
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HA2; MHAG; HLA-HA2
    Summary
    MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]
    Expression
    Biased expression in bone marrow (RPKM 19.0), spleen (RPKM 14.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    Location:
    7p13
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (44962662..44979015, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (45123008..45139360, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45002261..45018614, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44951201-44951702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44951703-44952202 Neighboring gene mitochondrial ribosomal protein S23 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44995675-44996176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45001789-45002289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25961 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:45024687-45024867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45025394-45026140 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45026141-45026888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45030540-45031094 Neighboring gene uncharacterized LOC102723334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25965 Neighboring gene small nucleolar RNA host gene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18161 Neighboring gene small nucleolar RNA, H/ACA box 9 Neighboring gene CCM2 scaffold protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of myosin IG (MYO1G) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC142104

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylinositol-3,4-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway involved in phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T cell meandering migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell mediated immunity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell gliding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in leading edge membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in phagocytic cup ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    unconventional myosin-Ig
    Names
    minor histocompatibility antigen HA-2
    myosin-Ig

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033054.3NP_149043.2  unconventional myosin-Ig

      See identical proteins and their annotated locations for NP_149043.2

      Status: VALIDATED

      Source sequence(s)
      AA651942, AC004847, BC117241
      Consensus CDS
      CCDS34629.1
      UniProtKB/Swiss-Prot
      B0I1T2, Q8TEI9, Q8TES2, Q96BE2, Q96RI5, Q96RI6
      UniProtKB/TrEMBL
      A0A3B3IU30
      Related
      ENSP00000258787.7, ENST00000258787.12
      Conserved Domains (3) summary
      smart00242
      Location:4706
      MYSc; Myosin. Large ATPases
      cd01378
      Location:23694
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:815980
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      44962662..44979015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007060129.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      45123008..45139360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008487727.1 RNA Sequence