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    Gmfb glia maturation factor, beta [ Mus musculus (house mouse) ]

    Gene ID: 63985, updated on 18-Sep-2024

    Summary

    Official Symbol
    Gmfbprovided by MGI
    Official Full Name
    glia maturation factor, betaprovided by MGI
    Primary source
    MGI:MGI:1927133
    See related
    Ensembl:ENSMUSG00000062014 AllianceGenome:MGI:1927133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D14Ertd630e; 3110001H22Rik; 3110001O16Rik
    Summary
    Predicted to enable Arp2/3 complex binding activity. Acts upstream of or within learning and locomotory behavior. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina layer; and spleen. Orthologous to human GMFB (glia maturation factor beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 25.4), frontal lobe adult (RPKM 21.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Gmfb in Genome Data Viewer
    Location:
    14 C1; 14 24.32 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47045606..47059711, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (46808149..46822259, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E752 Neighboring gene cyclin dependent kinase inhibitor 3 Neighboring gene cornichon family AMPA receptor auxiliary protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7306 Neighboring gene STARR-positive B cell enhancer ABC_E5430 Neighboring gene cell growth regulator with ring finger domain 1 Neighboring gene predicted gene, 34934

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Arp2/3 complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament debranching IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament debranching IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    glia maturation factor beta
    Names
    GMF-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022023.2NP_071306.2  glia maturation factor beta

      See identical proteins and their annotated locations for NP_071306.2

      Status: VALIDATED

      Source sequence(s)
      AC093043
      Consensus CDS
      CCDS36898.1
      UniProtKB/Swiss-Prot
      Q3UQX5, Q9CQI3, Q9ERL8
      UniProtKB/TrEMBL
      A0A2I3BPS1
      Related
      ENSMUSP00000107448.2, ENSMUST00000111817.8
      Conserved Domains (1) summary
      cd11283
      Location:9130
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      47045606..47059711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247909.2XP_030103769.1  glia maturation factor beta isoform X1

      UniProtKB/TrEMBL
      A0A2I3BPS1, Q80X87
      Conserved Domains (1) summary
      cd11283
      Location:9131
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins
    2. XM_030247913.1XP_030103773.1  glia maturation factor beta isoform X3

      Conserved Domains (1) summary
      cd11283
      Location:197
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins
    3. XM_036158778.1XP_036014671.1  glia maturation factor beta isoform X3

      Conserved Domains (1) summary
      cd11283
      Location:197
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins
    4. XM_030247912.1XP_030103772.1  glia maturation factor beta isoform X3

      Conserved Domains (1) summary
      cd11283
      Location:197
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins
    5. XM_030247911.1XP_030103771.1  glia maturation factor beta isoform X3

      Conserved Domains (1) summary
      cd11283
      Location:197
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins
    6. XM_030247910.1XP_030103770.1  glia maturation factor beta isoform X2

      Conserved Domains (1) summary
      cd11283
      Location:198
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins