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    Dusp10 dual specificity phosphatase 10 [ Mus musculus (house mouse) ]

    Gene ID: 63953, updated on 9-Sep-2018

    Summary

    Official Symbol
    Dusp10provided by MGI
    Official Full Name
    dual specificity phosphatase 10provided by MGI
    Primary source
    MGI:MGI:1927070
    See related
    Ensembl:ENSMUSG00000039384 Vega:OTTMUSG00000033984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MKP5; MKP-5; AI158871; 2610306G15Rik
    Expression
    Broad expression in thymus adult (RPKM 37.9), testis adult (RPKM 13.3) and 21 other tissues See more
    Orthologs

    Genomic context

    See Dusp10 in Genome Data Viewer
    Location:
    1; 1 H5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (184034461..184075636)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (185858340..185899515)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700056E22 gene Neighboring gene predicted gene, 39725 Neighboring gene predicted gene, 34177 Neighboring gene predicted gene, 34229

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    JUN kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    MAP kinase phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAP kinase phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    MAP kinase tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mitogen-activated protein kinase p38 binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    inactivation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelium regeneration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity by regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of respiratory burst involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-threonine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of adaptive immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dual specificity protein phosphatase 10
    Names
    MAP kinase phosphatase 5
    mitogen-activated protein kinase phosphatase 5
    NP_071302.2
    XP_006497251.1
    XP_006497252.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022019.6NP_071302.2  dual specificity protein phosphatase 10

      See identical proteins and their annotated locations for NP_071302.2

      Status: VALIDATED

      Source sequence(s)
      AK142568, BY283666, CK626309
      Consensus CDS
      CCDS15591.1
      UniProtKB/Swiss-Prot
      Q9ESS0
      Related
      ENSMUSP00000045838.7, OTTMUSP00000046360, ENSMUST00000048655.7
      Conserved Domains (2) summary
      cd00127
      Location:322460
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:150285
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      184034461..184075636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497189.1XP_006497252.1  dual specificity protein phosphatase 10 isoform X1

      See identical proteins and their annotated locations for XP_006497252.1

      UniProtKB/Swiss-Prot
      Q9ESS0
      Conserved Domains (2) summary
      cd00127
      Location:322460
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:150285
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    2. XM_006497188.2XP_006497251.1  dual specificity protein phosphatase 10 isoform X1

      See identical proteins and their annotated locations for XP_006497251.1

      UniProtKB/Swiss-Prot
      Q9ESS0
      Conserved Domains (2) summary
      cd00127
      Location:322460
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:150285
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
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