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    ZNF667 zinc finger protein 667 [ Homo sapiens (human) ]

    Gene ID: 63934, updated on 5-Mar-2024

    Summary

    Official Symbol
    ZNF667provided by HGNC
    Official Full Name
    zinc finger protein 667provided by HGNC
    Primary source
    HGNC:HGNC:28854
    See related
    Ensembl:ENSG00000198046 MIM:611024; AllianceGenome:HGNC:28854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIPU1
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 3.0), thyroid (RPKM 2.8) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF667 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56439329..56478093, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59533762..59572529, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56950698..56988714, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF582 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15119 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11069 Neighboring gene zinc finger protein 583 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:56968363-56969562 Neighboring gene ZNF667 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105372471 Neighboring gene uncharacterized LOC124904776

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14011, FLJ45518, DKFZp686O111

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 667
    Names
    myocardial ischemic preconditioning upregulated 1 ortholog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321355.2NP_001308284.1  zinc finger protein 667 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC006116, AC013256, AC098795
      UniProtKB/TrEMBL
      Q5CZB4
      Conserved Domains (3) summary
      COG5048
      Location:84544
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:444464
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:456481
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001321356.2NP_001308285.1  zinc finger protein 667 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC006116, AC013256, AC098795
      Consensus CDS
      CCDS12944.1
      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Related
      ENSP00000439402.1, ENST00000504904.8
      Conserved Domains (3) summary
      smart00349
      Location:1574
      KRAB; krueppel associated box
      COG5048
      Location:141601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. NM_022103.4NP_071386.3  zinc finger protein 667 isoform 1

      See identical proteins and their annotated locations for NP_071386.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
      Source sequence(s)
      AC006116, AC013256, AC098795
      Consensus CDS
      CCDS12944.1
      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Related
      ENSP00000292069.5, ENST00000292069.10
      Conserved Domains (3) summary
      smart00349
      Location:1574
      KRAB; krueppel associated box
      COG5048
      Location:141601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      56439329..56478093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451637.2XP_024307405.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:1574
      KRAB; krueppel associated box
      COG5048
      Location:141601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_024451642.2XP_024307410.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:1574
      KRAB; krueppel associated box
      COG5048
      Location:141601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. XM_047439212.1XP_047295168.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    4. XM_024451646.2XP_024307414.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:1574
      KRAB; krueppel associated box
      COG5048
      Location:141601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. XM_024451647.2XP_024307415.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:1574
      KRAB; krueppel associated box
      COG5048
      Location:141601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. XM_024451644.2XP_024307412.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:1574
      KRAB; krueppel associated box
      COG5048
      Location:141601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. XM_024451643.2XP_024307411.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:1574
      KRAB; krueppel associated box
      COG5048
      Location:141601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]
    8. XM_024451645.2XP_024307413.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:1574
      KRAB; krueppel associated box
      COG5048
      Location:141601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]
    9. XM_011527208.3XP_011525510.1  zinc finger protein 667 isoform X1

      See identical proteins and their annotated locations for XP_011525510.1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:1574
      KRAB; krueppel associated box
      COG5048
      Location:141601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]
    10. XM_047439211.1XP_047295167.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    11. XM_047439208.1XP_047295164.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    12. XM_024451641.2XP_024307409.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:1574
      KRAB; krueppel associated box
      COG5048
      Location:141601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]
    13. XM_024451640.2XP_024307408.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:1574
      KRAB; krueppel associated box
      COG5048
      Location:141601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]
    14. XM_047439209.1XP_047295165.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    15. XM_047439210.1XP_047295166.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    16. XM_047439207.1XP_047295163.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
    17. XM_024451638.2XP_024307406.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:1574
      KRAB; krueppel associated box
      COG5048
      Location:141601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      59533762..59572529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321728.1XP_054177703.1  zinc finger protein 667 isoform X1

    2. XM_054321714.1XP_054177689.1  zinc finger protein 667 isoform X1

    3. XM_054321722.1XP_054177697.1  zinc finger protein 667 isoform X1

    4. XM_054321726.1XP_054177701.1  zinc finger protein 667 isoform X1

    5. XM_054321729.1XP_054177704.1  zinc finger protein 667 isoform X1

    6. XM_054321725.1XP_054177700.1  zinc finger protein 667 isoform X1

    7. XM_054321720.1XP_054177695.1  zinc finger protein 667 isoform X1

    8. XM_054321715.1XP_054177690.1  zinc finger protein 667 isoform X1

    9. XM_054321721.1XP_054177696.1  zinc finger protein 667 isoform X1

    10. XM_054321717.1XP_054177692.1  zinc finger protein 667 isoform X1

    11. XM_054321730.1XP_054177705.1  zinc finger protein 667 isoform X1

    12. XM_054321719.1XP_054177694.1  zinc finger protein 667 isoform X1

    13. XM_054321727.1XP_054177702.1  zinc finger protein 667 isoform X1

    14. XM_054321716.1XP_054177691.1  zinc finger protein 667 isoform X1

    15. XM_054321718.1XP_054177693.1  zinc finger protein 667 isoform X1

    16. XM_054321723.1XP_054177698.1  zinc finger protein 667 isoform X1

    17. XM_054321724.1XP_054177699.1  zinc finger protein 667 isoform X1