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    MRPS14 mitochondrial ribosomal protein S14 [ Homo sapiens (human) ]

    Gene ID: 63931, updated on 5-May-2024

    Summary

    Official Symbol
    MRPS14provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein S14provided by HGNC
    Primary source
    HGNC:HGNC:14049
    See related
    Ensembl:ENSG00000120333 MIM:611978; AllianceGenome:HGNC:14049
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S14mt; uS14m; COXPD38; MRP-S14; HSMRPS14; DJ262D12.2
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
    Expression
    Ubiquitous expression in brain (RPKM 14.6), thyroid (RPKM 14.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MRPS14 in Genome Data Viewer
    Location:
    1q25.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (175012958..175023425, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (174366714..174377180, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (174982094..174992561, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:174968357-174968892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1566 Neighboring gene RNA, U6 small nuclear 307, pseudogene Neighboring gene calcyclin binding protein Neighboring gene MPRA-validated peak469 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2128 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:175012695-175013230 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:175013231-175013766 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:175023596-175024795 Neighboring gene ENTR1 pseudogene 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:175036290-175037489 Neighboring gene tenascin N Neighboring gene MPRA-validated peak471 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:175098412-175099320 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:175099321-175100227

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrial ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of mitochondrial small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    small ribosomal subunit protein uS14m
    Names
    28S ribosomal protein S14, mitochondrial
    mitochondrial 28S ribosomal protein S14
    mitochondrial small ribosomal subunit protein uS14m
    NP_071383.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022100.3NP_071383.1  small ribosomal subunit protein uS14m

      See identical proteins and their annotated locations for NP_071383.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
      Source sequence(s)
      AI086885, AL049705, BE882322, DA610441
      Consensus CDS
      CCDS1316.1
      UniProtKB/Swiss-Prot
      O60783, Q5R358
      UniProtKB/TrEMBL
      B2R4A5
      Related
      ENSP00000420714.1, ENST00000476371.1
      Conserved Domains (1) summary
      pfam00253
      Location:74126
      Ribosomal_S14; Ribosomal protein S14p/S29e

    RNA

    1. NR_037606.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI086885, AK310915, AL049705, BE882322, DA610441

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      175012958..175023425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      174366714..174377180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)