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    CXCL5 C-X-C motif chemokine ligand 5 [ Homo sapiens (human) ]

    Gene ID: 6374, updated on 27-Nov-2024

    Summary

    Official Symbol
    CXCL5provided by HGNC
    Official Full Name
    C-X-C motif chemokine ligand 5provided by HGNC
    Primary source
    HGNC:HGNC:10642
    See related
    Ensembl:ENSG00000163735 MIM:600324; AllianceGenome:HGNC:10642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCYB5; ENA-78
    Summary
    This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Biased expression in appendix (RPKM 23.4), urinary bladder (RPKM 8.7) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CXCL5 in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (73995642..73998677, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (77339277..77342312, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (74861359..74864394, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:74846696-74847437 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:74850560-74851073 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:74851074-74851586 Neighboring gene platelet factor 4 Neighboring gene pro-platelet basic protein Neighboring gene uncharacterized LOC124900715 Neighboring gene RNA, 7SL, cytoplasmic 218, pseudogene Neighboring gene C-X-C motif chemokine ligand 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of chemokine (C-X-C motif) ligand 5 (CXCL5) in peptide-treated PBMCs PubMed
    Tat tat HIV-1 Tat upregulates the expression of chemokine (C-X-C motif) ligand 5 (CXCL5) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CXCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    C-X-C motif chemokine 5
    Names
    chemokine (C-X-C motif) ligand 5
    epithelial-derived neutrophil-activating protein 78
    neutrophil-activating peptide ENA-78
    neutrophil-activating protein 78
    small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002994.5NP_002985.1  C-X-C motif chemokine 5 precursor

      See identical proteins and their annotated locations for NP_002985.1

      Status: REVIEWED

      Source sequence(s)
      AC097709
      Consensus CDS
      CCDS34006.1
      UniProtKB/Swiss-Prot
      P42830, Q96QE1
      UniProtKB/TrEMBL
      Q6I9S7
      Related
      ENSP00000296027.4, ENST00000296027.5
      Conserved Domains (1) summary
      cd00273
      Location:46107
      Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      73995642..73998677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      77339277..77342312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)