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    Trim71 tripartite motif-containing 71 [ Mus musculus (house mouse) ]

    Gene ID: 636931, updated on 5-Aug-2018

    Summary

    Official Symbol
    Trim71provided by MGI
    Official Full Name
    tripartite motif-containing 71provided by MGI
    Primary source
    MGI:MGI:2685973
    See related
    Ensembl:ENSMUSG00000079259 Vega:OTTMUSG00000044351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lin41; Gm1127; lin-41; mLin41; mlin-41; AL022943; 2610206G21Rik
    Expression
    Biased expression in placenta adult (RPKM 2.7), CNS E11.5 (RPKM 0.9) and 4 other tissues See more
    Orthologs

    Genomic context

    See Trim71 in Genome Data Viewer
    Location:
    9; 9 F3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (114511268..114564369, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (114420386..114473487, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene galactosidase, beta 1 Neighboring gene predicted gene, 30254 Neighboring gene chemokine (C-C motif) receptor 4 Neighboring gene CCR4-NOT transcription complex, subunit 10 Neighboring gene predicted gene 7780

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (3) 
    • Targeted (2) 

    Pathways from BioSystems

    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    3'-UTR-mediated mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA mediated inhibition of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    miRNA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural tube development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene silencing by miRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    posttranscriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    production of miRNAs involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of gene silencing by miRNA IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    P-body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM71
    Names
    RING-type E3 ubiquitin transferase TRIM71
    lin-41 homolog
    protein lin-41 homolog
    tripartite motif-containing protein 71
    NP_001035968.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042503.2NP_001035968.1  E3 ubiquitin-protein ligase TRIM71

      See identical proteins and their annotated locations for NP_001035968.1

      Status: VALIDATED

      Source sequence(s)
      AC164109
      Consensus CDS
      CCDS40793.1
      UniProtKB/Swiss-Prot
      Q1PSW8
      Related
      ENSMUSP00000107447.1, OTTMUSP00000065111, ENSMUST00000111816.2, OTTMUST00000116728
      Conserved Domains (6) summary
      smart00557
      Location:471568
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14954
      Location:571855
      NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
      pfam00630
      Location:469564
      Filamin; Filamin/ABP280 repeat
      pfam00643
      Location:265298
      zf-B_box; B-box zinc finger
      sd00039
      Location:691727
      7WD40; WD40 repeat [structural motif]
      cl23765
      Location:301431
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      114511268..114564369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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