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    Trim71 tripartite motif-containing 71 [ Mus musculus (house mouse) ]

    Gene ID: 636931, updated on 26-Sep-2022

    Summary

    Official Symbol
    Trim71provided by MGI
    Official Full Name
    tripartite motif-containing 71provided by MGI
    Primary source
    MGI:MGI:2685973
    See related
    Ensembl:ENSMUSG00000079259 AllianceGenome:MGI:2685973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lin41; Gm1127; lin-41; mLin41; mlin-41; 2610206G21Rik
    Summary
    Enables miRNA binding activity and ubiquitin protein ligase activity. Involved in several processes, including miRNA metabolic process; protein autoubiquitination; and regulation of gene expression. Acts upstream of or within several processes, including neural tube closure; positive regulation of gene silencing by miRNA; and regulation of protein metabolic process. Located in P-body. Is expressed in several structures, including dorsal root ganglion; ileum; limb bud; male reproductive gland or organ; and tail. Orthologous to human TRIM71 (tripartite motif containing 71). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 2.7), CNS E11.5 (RPKM 0.9) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Trim71 in Genome Data Viewer
    Location:
    9; 9 F3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (114340336..114393437, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (114511268..114564369, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene galactosidase, beta 1 Neighboring gene predicted gene, 30254 Neighboring gene chemokine (C-C motif) receptor 4 Neighboring gene predicted gene, 53512 Neighboring gene CCR4-NOT transcription complex, subunit 10 Neighboring gene predicted gene, 51659

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (3) 
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within RNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in miRNA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in miRNA-mediated gene silencing by inhibition of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural tube development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of miRNA-mediated gene silencing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of miRNA-mediated gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of miRNA-mediated gene silencing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of miRNA-mediated gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM71
    Names
    RING-type E3 ubiquitin transferase TRIM71
    lin-41 homolog
    protein lin-41 homolog
    tripartite motif-containing protein 71
    NP_001035968.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042503.2NP_001035968.1  E3 ubiquitin-protein ligase TRIM71

      See identical proteins and their annotated locations for NP_001035968.1

      Status: VALIDATED

      Source sequence(s)
      AC164109
      Consensus CDS
      CCDS40793.1
      UniProtKB/Swiss-Prot
      Q1PSW8
      Related
      ENSMUSP00000107447.2, ENSMUST00000111816.3
      Conserved Domains (6) summary
      smart00557
      Location:471568
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14954
      Location:571855
      NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
      pfam00630
      Location:469564
      Filamin; Filamin/ABP280 repeat
      pfam00643
      Location:265298
      zf-B_box; B-box zinc finger
      sd00039
      Location:691727
      7WD40; WD40 repeat [structural motif]
      cl23765
      Location:301431
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      114340336..114393437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)