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    S100A9 S100 calcium binding protein A9 [ Homo sapiens (human) ]

    Gene ID: 6280, updated on 10-Jun-2024

    Summary

    Official Symbol
    S100A9provided by HGNC
    Official Full Name
    S100 calcium binding protein A9provided by HGNC
    Primary source
    HGNC:HGNC:10499
    See related
    Ensembl:ENSG00000163220 MIM:123886; AllianceGenome:HGNC:10499
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIF; NIF; P14; CAGB; CFAG; CGLB; L1AG; LIAG; MRP14; 60B8AG; MAC387; S100-A9
    Summary
    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014]
    Expression
    Biased expression in bone marrow (RPKM 7440.5), esophagus (RPKM 5956.4) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See S100A9 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153357854..153361023)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152495082..152498250)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153330330..153333499)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene peptidoglycan recognition protein 3 Neighboring gene RNA, U6 small nuclear 160, pseudogene Neighboring gene peptidoglycan recognition protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1340 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:153352860-153353030 Neighboring gene S100 calcium binding protein A12 Neighboring gene lysosomal protein transmembrane 4 beta pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Clinical HIV-1 infection decreases S100A9 in blood plasma of patients with symptomatic neurocognitive disorders PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RAGE receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables Toll-like receptor 4 binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables arachidonic acid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in astrocyte development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autocrine signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chronic inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to bacterium TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in defense response to fungus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte migration involved in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in leukocyte migration involved in inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of process of another organism IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neutrophil aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neutrophil aggregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-cysteine S-nitrosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-cysteine S-trans-nitrosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell growth TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of integrin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of respiratory burst involved in inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of toll-like receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sequestering of zinc ion TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    protein S100-A9
    Names
    MRP-14
    calgranulin B
    calprotectin L1H subunit
    leukocyte L1 complex heavy chain
    migration inhibitory factor-related protein 14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002965.4NP_002956.1  protein S100-A9

      See identical proteins and their annotated locations for NP_002956.1

      Status: REVIEWED

      Source sequence(s)
      BC047681, X06233
      Consensus CDS
      CCDS1036.1
      UniProtKB/Swiss-Prot
      D3DV36, P06702, Q6FGA1, Q9NYM0, Q9UCJ1
      UniProtKB/TrEMBL
      B2R4M6
      Related
      ENSP00000357727.3, ENST00000368738.4
      Conserved Domains (1) summary
      cd05030
      Location:694
      calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      153357854..153361023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      152495082..152498250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)