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    RRAS RAS related [ Homo sapiens (human) ]

    Gene ID: 6237, updated on 11-Jun-2021

    Summary

    Official Symbol
    RRASprovided by HGNC
    Official Full Name
    RAS relatedprovided by HGNC
    Primary source
    HGNC:HGNC:10447
    See related
    Ensembl:ENSG00000126458 MIM:165090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    R-Ras
    Summary
    The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]
    Expression
    Ubiquitous expression in fat (RPKM 75.3), lung (RPKM 63.7) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RRAS in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49635292..49640143, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50138549..50143400, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene proline rich and Gla domain 2 Neighboring gene proline rich 12 Neighboring gene SR-related CTD associated factor 1 Neighboring gene interferon regulatory factor 3 Neighboring gene BCL2 like 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Biological insights from 108 schizophrenia-associated genetic loci.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GDP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ras-related protein R-Ras
    Names
    oncogene RRAS
    p23
    ras family small GTP binding protein R-Ras
    related RAS viral (r-ras) oncogene homolog
    NP_006261.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042222.1 RefSeqGene

      Range
      5001..9852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006270.5NP_006261.1  ras-related protein R-Ras

      See identical proteins and their annotated locations for NP_006261.1

      Status: REVIEWED

      Source sequence(s)
      BC016286, BC016318
      Consensus CDS
      CCDS12774.1
      UniProtKB/Swiss-Prot
      P10301
      UniProtKB/TrEMBL
      A0A024QZF2
      Related
      ENSP00000246792.2, ENST00000246792.4
      Conserved Domains (1) summary
      cd04145
      Location:28191
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      49635292..49640143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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