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    RPS27 ribosomal protein S27 [ Homo sapiens (human) ]

    Gene ID: 6232, updated on 17-Sep-2024

    Summary

    Official Symbol
    RPS27provided by HGNC
    Official Full Name
    ribosomal protein S27provided by HGNC
    Primary source
    HGNC:HGNC:10416
    See related
    Ensembl:ENSG00000177954 MIM:603702; AllianceGenome:HGNC:10416
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S27; MPS1; eS27; DBA17; MPS-1
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2018]
    Expression
    Ubiquitous expression in ovary (RPKM 2236.6), lymph node (RPKM 1431.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RPS27 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153990762..153992155)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (153128025..153129418)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153963238..153964631)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:153949621-153950269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1770 Neighboring gene Sharpr-MPRA regulatory region 11874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1771 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:153958417-153958918 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:153962963-153964162 Neighboring gene JTB divergent transcript Neighboring gene uncharacterized LOC124904673 Neighboring gene RAB13, member RAS oncogene family Neighboring gene nucleoporin 210 like Neighboring gene ribosomal protein L34 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ribosomal protein S27 (RPS27) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytosolic small ribosomal subunit HDA PubMed 
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    small ribosomal subunit protein eS27
    Names
    metallopan-stimulin 1
    metallopanstimulin 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053102.2 RefSeqGene

      Range
      5008..6401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1158

    mRNA and Protein(s)

    1. NM_001030.6NP_001021.1  small ribosomal subunit protein eS27 isoform 1

      See identical proteins and their annotated locations for NP_001021.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AJ572583, BC070219, D28454
      Consensus CDS
      CCDS1059.1
      UniProtKB/Swiss-Prot
      P42677, Q5T4L6
      UniProtKB/TrEMBL
      H0YMV8
      Related
      ENSP00000499044.1, ENST00000651669.1
      Conserved Domains (1) summary
      PLN00209
      Location:682
      PLN00209; ribosomal protein S27; Provisional
    2. NM_001349946.2NP_001336875.1  small ribosomal subunit protein eS27 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in its 5' UTR and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AJ572583, BC070219, CN270933
      UniProtKB/TrEMBL
      C9J1C5
      Conserved Domains (1) summary
      cl00897
      Location:150
      Ribosomal_S27e; Ribosomal protein S27
    3. NM_001349947.2NP_001336876.1  small ribosomal subunit protein eS27 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) retains an intron in its 5' UTR compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AJ572583, BC070219, BP276426
      UniProtKB/TrEMBL
      C9J1C5
      Related
      ENST00000493224.5
      Conserved Domains (1) summary
      cl00897
      Location:150
      Ribosomal_S27e; Ribosomal protein S27

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      153990762..153992155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      153128025..153129418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)