Format

Send to:

Choose Destination
    • Showing Current items.

    RPS20 ribosomal protein S20 [ Homo sapiens (human) ]

    Gene ID: 6224, updated on 8-Jul-2021

    Summary

    Official Symbol
    RPS20provided by HGNC
    Official Full Name
    ribosomal protein S20provided by HGNC
    Primary source
    HGNC:HGNC:10405
    See related
    Ensembl:ENSG00000008988 MIM:603682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S20; uS10
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10P family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the small nucleolar RNA gene U54, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2009]
    Expression
    Ubiquitous expression in ovary (RPKM 727.4), fat (RPKM 436.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RPS20 in Genome Data Viewer
    Location:
    8q12.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (56067254..56074506, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (56979813..56987065, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 323, pseudogene Neighboring gene proteasome 26S subunit, ATPase, 6 pseudogene 1 Neighboring gene small nucleolar RNA, C/D box 54 Neighboring gene competing endogenous lncRNA 3 for miR-645 Neighboring gene nucleophosmin 1 pseudogene 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Many sequence variants affecting diversity of adult human height.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that ribosomal protein S20 (RPS20) is a Nef-binding protein in Jurkat cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ27451, MGC102930

    Gene Ontology Provided by GOA

    General protein information

    Preferred Names
    40S ribosomal protein S20
    Names
    small ribosomal subunit protein uS10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042872.1 RefSeqGene

      Range
      5076..12287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023.4NP_001014.1  40S ribosomal protein S20 isoform 2

      See identical proteins and their annotated locations for NP_001014.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC007507, CB138358
      Consensus CDS
      CCDS6163.1
      UniProtKB/Swiss-Prot
      P60866
      Related
      ENSP00000009589.3, ENST00000009589.8
      Conserved Domains (1) summary
      cl00314
      Location:16116
      Ribosomal_S10; Ribosomal protein S10p/S20e
    2. NM_001146227.3NP_001139699.1  40S ribosomal protein S20 isoform 1

      See identical proteins and their annotated locations for NP_001139699.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC107376, AK301342, CD671362
      Consensus CDS
      CCDS55231.1
      UniProtKB/Swiss-Prot
      P60866
      Related
      ENSP00000429374.1, ENST00000519807.5
      Conserved Domains (1) summary
      cl00314
      Location:16112
      Ribosomal_S10; Ribosomal protein S10p/S20e

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      56067254..56074506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center