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    RPS14 ribosomal protein S14 [ Homo sapiens (human) ]

    Gene ID: 6208, updated on 7-Jul-2024

    Summary

    Official Symbol
    RPS14provided by HGNC
    Official Full Name
    ribosomal protein S14provided by HGNC
    Primary source
    HGNC:HGNC:10387
    See related
    Ensembl:ENSG00000164587 MIM:130620; AllianceGenome:HGNC:10387
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S14; EMTB; uS11
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 306.3), bone marrow (RPKM 258.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RPS14 in Genome Data Viewer
    Location:
    5q33.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (150442635..150449739, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (150979169..150986273, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (149822198..149829302, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149792263-149792832 Neighboring gene CD74 molecule Neighboring gene uncharacterized LOC124901106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:149807381-149807882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:149807883-149808382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23415 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23416 Neighboring gene MPRA-validated peak5536 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149820554-149821093 Neighboring gene MPRA-validated peak5537 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149828819-149829757 Neighboring gene MPRA-validated peak5538 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149840208-149840834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149843737-149844462 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82371 Neighboring gene NDST1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:149865131-149865786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149872150-149872771 Neighboring gene Sharpr-MPRA regulatory region 285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:149881034-149881594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:149881595-149882153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:149889677-149890250 Neighboring gene Sharpr-MPRA regulatory region 361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149891552-149892205 Neighboring gene N-deacetylase and N-sulfotransferase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:149902065-149902942 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149905099-149905839 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149916701-149917473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:149919751-149920250 Neighboring gene Sharpr-MPRA regulatory region 2793 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Myelodysplastic syndrome associated with isolated del(5q)
    MedGen: C0740302 OMIM: 153550 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maturation of SSU-rRNA ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ribosomal small subunit assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    small ribosomal subunit protein uS11
    Names
    40S ribosomal protein S14
    emetine resistance

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042287.1 RefSeqGene

      Range
      5018..12122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1139

    mRNA and Protein(s)

    1. NM_001025070.2NP_001020241.1  small ribosomal subunit protein uS11

      See identical proteins and their annotated locations for NP_001020241.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a small segment in the 5' UTR, as compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AA467888, AC011388, BM454896
      Consensus CDS
      CCDS4307.1
      UniProtKB/Swiss-Prot
      B2R5G5, D3DQG5, P06366, P62263, Q5BJI0
      UniProtKB/TrEMBL
      A0A2R8Y811
      Related
      ENSP00000385958.3, ENST00000401695.8
      Conserved Domains (1) summary
      PTZ00129
      Location:1140
      PTZ00129; 40S ribosomal protein S14; Provisional
    2. NM_001025071.2NP_001020242.1  small ribosomal subunit protein uS11

      See identical proteins and their annotated locations for NP_001020242.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AA467888, AC011388, BM557014
      Consensus CDS
      CCDS4307.1
      UniProtKB/Swiss-Prot
      B2R5G5, D3DQG5, P06366, P62263, Q5BJI0
      UniProtKB/TrEMBL
      A0A2R8Y811
      Related
      ENSP00000311028.5, ENST00000312037.6
      Conserved Domains (1) summary
      PTZ00129
      Location:1140
      PTZ00129; 40S ribosomal protein S14; Provisional
    3. NM_005617.4NP_005608.1  small ribosomal subunit protein uS11

      See identical proteins and their annotated locations for NP_005608.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a big segment in the 5' UTR, as compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AA467888, AC011388, BC006784
      Consensus CDS
      CCDS4307.1
      UniProtKB/Swiss-Prot
      B2R5G5, D3DQG5, P06366, P62263, Q5BJI0
      UniProtKB/TrEMBL
      A0A2R8Y811
      Related
      ENSP00000385425.1, ENST00000407193.7
      Conserved Domains (1) summary
      PTZ00129
      Location:1140
      PTZ00129; 40S ribosomal protein S14; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      150442635..150449739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      150979169..150986273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005616.1: Suppressed sequence

      Description
      NM_005616.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.