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    RPLP1 ribosomal protein lateral stalk subunit P1 [ Homo sapiens (human) ]

    Gene ID: 6176, updated on 17-Jun-2024

    Summary

    Official Symbol
    RPLP1provided by HGNC
    Official Full Name
    ribosomal protein lateral stalk subunit P1provided by HGNC
    Primary source
    HGNC:HGNC:10372
    See related
    Ensembl:ENSG00000137818 MIM:180520; AllianceGenome:HGNC:10372
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P1; LP1; RPP1
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 1137.8), ovary (RPKM 979.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RPLP1 in Genome Data Viewer
    Location:
    15q23
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (69452818..69456205)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (67274899..67278285)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69745157..69748544)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member 5 Neighboring gene KIF23 and PAQR5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6599 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 pseudogene Neighboring gene kinesin family member 23 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9656 Neighboring gene small nucleolar RNA U3 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr15:69754627-69755133 and GRCh37_chr15:69755134-69755641 Neighboring gene long intergenic non-protein coding RNA 2896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9657 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69791851-69792352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9658 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:69818533-69819113 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:69819114-69819694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69850399-69850902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69850903-69851404 Neighboring gene uncharacterized LOC124903517 Neighboring gene downregulated RNA in cancer, inhibitor of cell invasion and migration

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC5215, FLJ27448

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    large ribosomal subunit protein P1
    Names
    60S acidic ribosomal protein P1
    acidic ribosomal phosphoprotein P1
    ribosomal protein, large, P1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003.3NP_000994.1  large ribosomal subunit protein P1 isoform 1

      See identical proteins and their annotated locations for NP_000994.1

      Status: REVIEWED

      Description
      Transcript Variant: This predominant variant (1) is the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC027237
      Consensus CDS
      CCDS10233.1
      UniProtKB/Swiss-Prot
      A6NIB2, P05386
      UniProtKB/TrEMBL
      Q6ICQ4, Q7Z612
      Related
      ENSP00000346037.5, ENST00000260379.11
      Conserved Domains (1) summary
      cd05831
      Location:663
      Ribosomal_P1; Ribosomal protein P1. This subfamily represents the eukaryotic large ribosomal protein P1. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P1 is located in the L12 stalk, with proteins ...
    2. NM_213725.2NP_998890.1  large ribosomal subunit protein P1 isoform 2

      See identical proteins and their annotated locations for NP_998890.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) when compared to isoform 1.
      Source sequence(s)
      AC027237, BM745938, M17886
      Consensus CDS
      CCDS10234.1
      UniProtKB/Swiss-Prot
      P05386
      Related
      ENSP00000350437.5, ENST00000357790.5
      Conserved Domains (1) summary
      cl21508
      Location:688
      Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      69452818..69456205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      67274899..67278285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)