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    RPL31 ribosomal protein L31 [ Homo sapiens (human) ]

    Gene ID: 6160, updated on 5-May-2024

    Summary

    Official Symbol
    RPL31provided by HGNC
    Official Full Name
    ribosomal protein L31provided by HGNC
    Primary source
    HGNC:HGNC:10334
    See related
    Ensembl:ENSG00000071082 MIM:617415; AllianceGenome:HGNC:10334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L31; eL31
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 450.2), bone marrow (RPKM 284.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RPL31 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101002289..101019724)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101460986..101478421)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101618751..101636186)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373508 Neighboring gene neuronal PAS domain protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101504140-101504909 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:101518843-101520042 Neighboring gene Sharpr-MPRA regulatory region 12407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101599407-101599908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101599909-101600408 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:101601340-101601535 Neighboring gene NPAS2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101607367-101608009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101611812-101612312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16296 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:101619087-101619741 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:101621211-101621711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16297 Neighboring gene ubiquitin specific peptidase 15 pseudogene Neighboring gene uncharacterized LOC105373510 Neighboring gene TBC1 domain family member 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101661499-101662000 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:101663058-101663602 Neighboring gene BBSome interacting protein 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC88191

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    large ribosomal subunit protein eL31
    Names
    60S ribosomal protein L31

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000993.5NP_000984.1  large ribosomal subunit protein eL31 isoform 1

      See identical proteins and their annotated locations for NP_000984.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
      Source sequence(s)
      AC016738, BC017343, BC070373, DA869102
      Consensus CDS
      CCDS2049.1
      UniProtKB/Swiss-Prot
      B7Z4K2, D3DVJ4, P12947, P62899, Q53SQ5, Q6IRZ0, Q6LBJ6
      UniProtKB/TrEMBL
      B2R4C1
      Related
      ENSP00000264258.3, ENST00000264258.8
      Conserved Domains (1) summary
      pfam01198
      Location:19100
      Ribosomal_L31e; Ribosomal protein L31e
    2. NM_001098577.3NP_001092047.1  large ribosomal subunit protein eL31 isoform 2

      See identical proteins and their annotated locations for NP_001092047.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate terminal exon; the resulting isoform (2) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC016738, BE564858, CN269912, CN269915, DA869102
      Consensus CDS
      CCDS46373.1
      UniProtKB/TrEMBL
      C9JU56
      Related
      ENSP00000386717.3, ENST00000409028.8
      Conserved Domains (1) summary
      pfam01198
      Location:19100
      Ribosomal_L31e; Ribosomal protein L31e
    3. NM_001099693.2NP_001093163.1  large ribosomal subunit protein eL31 isoform 3

      See identical proteins and their annotated locations for NP_001093163.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an unspliced 3' sequence compared to variant 1; the resulting isoform (3) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC070210, DA869102
      Consensus CDS
      CCDS46374.1
      UniProtKB/TrEMBL
      C9JU56
      Related
      ENSP00000387163.3, ENST00000409320.7
      Conserved Domains (1) summary
      pfam01198
      Location:19100
      Ribosomal_L31e; Ribosomal protein L31e

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      101002289..101019724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      101460986..101478421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)