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    TRAPPC11 trafficking protein particle complex subunit 11 [ Homo sapiens (human) ]

    Gene ID: 60684, updated on 4-Jul-2021

    Summary

    Official Symbol
    TRAPPC11provided by HGNC
    Official Full Name
    trafficking protein particle complex subunit 11provided by HGNC
    Primary source
    HGNC:HGNC:25751
    See related
    Ensembl:ENSG00000168538 MIM:614138
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRY; FOIGR; LGMD2S; C4orf41; LGMDR18
    Summary
    The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in adrenal (RPKM 9.6), thyroid (RPKM 9.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TRAPPC11 in Genome Data Viewer
    Location:
    4q35.1
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (183659277..183713592)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (184580446..184634742)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377580 Neighboring gene uncharacterized LOC107986329 Neighboring gene RNA, U6 small nuclear 479, pseudogene Neighboring gene RWD domain containing 4 Neighboring gene RNA, U6 small nuclear 335, pseudogene Neighboring gene RNA, U6 small nuclear 1053, pseudogene Neighboring gene uncharacterized LOC105377581 Neighboring gene storkhead box 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12716

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of TRAPP complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    trafficking protein particle complex subunit 11
    Names
    foie gras homolog
    gryzun homolog
    trafficking protein particle complex 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033102.1 RefSeqGene

      Range
      5027..59323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021942.6NP_068761.4  trafficking protein particle complex subunit 11 isoform a

      See identical proteins and their annotated locations for NP_068761.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AI034264, BX647127, BX648499
      Consensus CDS
      CCDS34112.1
      UniProtKB/Swiss-Prot
      Q7Z392
      Related
      ENSP00000335371.6, ENST00000334690.11
      Conserved Domains (2) summary
      pfam12742
      Location:10361095
      Gryzun-like; Gryzun, putative Golgi trafficking
      pfam11817
      Location:263522
      Foie-gras_1; Foie gras liver health family 1
    2. NM_199053.3NP_951008.1  trafficking protein particle complex subunit 11 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains alternate exon structure in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      BC051724, BX648499
      Consensus CDS
      CCDS47166.1
      UniProtKB/Swiss-Prot
      Q7Z392
      Related
      ENSP00000349738.4, ENST00000357207.8
      Conserved Domains (2) summary
      pfam11817
      Location:263522
      Foie-gras_1; Foie gras liver health family 1
      pfam12742
      Location:10361066
      Gryzun-like; Gryzun, putative Golgi trafficking

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

      Range
      183659277..183713592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008537.2XP_016864026.1  trafficking protein particle complex subunit 11 isoform X2

    2. XM_017008538.2XP_016864027.1  trafficking protein particle complex subunit 11 isoform X3

    3. XM_024454180.1XP_024309948.1  trafficking protein particle complex subunit 11 isoform X1

      Conserved Domains (2) summary
      pfam12742
      Location:10361095
      Gryzun-like; Gryzun, putative Golgi trafficking
      pfam11817
      Location:263522
      Foie-gras_1; Foie gras liver health family 1
    4. XM_024454181.1XP_024309949.1  trafficking protein particle complex subunit 11 isoform X4

      Related
      ENSP00000421004.1, ENST00000512476.1
      Conserved Domains (2) summary
      pfam12742
      Location:586645
      Gryzun-like; Gryzun, putative Golgi trafficking
      pfam11817
      Location:172
      Foie-gras_1; Foie gras liver health family 1
    5. XM_024454179.1XP_024309947.1  trafficking protein particle complex subunit 11 isoform X1

      Conserved Domains (2) summary
      pfam12742
      Location:10361095
      Gryzun-like; Gryzun, putative Golgi trafficking
      pfam11817
      Location:263522
      Foie-gras_1; Foie gras liver health family 1

    RNA

    1. XR_001741315.2 RNA Sequence

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