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    Wtap WT1 associating protein [ Mus musculus (house mouse) ]

    Gene ID: 60532, updated on 3-Aug-2021

    Summary

    Official Symbol
    Wtapprovided by MGI
    Official Full Name
    WT1 associating proteinprovided by MGI
    Primary source
    MGI:MGI:1926395
    See related
    Ensembl:ENSMUSG00000060475
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810408K05Rik; 9430038B09Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.9), CNS E18 (RPKM 10.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Wtap in Genome Data Viewer
    Location:
    17; 17 A1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13185686..13211430, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12966799..12992543, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (13159665..13185405, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene t-complex protein 1, pseudogene 2 Neighboring gene acetyl-Coenzyme A acetyltransferase 2 Neighboring gene predicted gene 15946 Neighboring gene superoxide dismutase 2, mitochondrial Neighboring gene predicted gene, 36117

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RNA N6-methyladenosine methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pre-mRNA-splicing regulator WTAP
    Names
    WT1-associated protein
    Wilms tumour 1-associating protein
    Wilms' tumour 1-associating protein
    female-lethal(2)D homolog
    wilms tumor 1-associating protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113532.1NP_001107004.1  pre-mRNA-splicing regulator WTAP isoform b

      See identical proteins and their annotated locations for NP_001107004.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a different 3' UTR, compared to variant 1. It encodes isoform b which is C-terminal truncated, compared to isoform a. Variants 2 and 3 encode the same isoform b.
      Source sequence(s)
      AK031965, AK041341, BC093504, BY016042
      Consensus CDS
      CCDS49949.1
      UniProtKB/Swiss-Prot
      Q9ER69
      Related
      ENSMUSP00000123961.2, ENSMUST00000159986.8
      Conserved Domains (1) summary
      pfam17098
      Location:68150
      Wtap; WTAP/Mum2p family
    2. NM_001113533.1NP_001107005.1  pre-mRNA-splicing regulator WTAP isoform a

      See identical proteins and their annotated locations for NP_001107005.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL589878
      Consensus CDS
      CCDS49950.1
      UniProtKB/TrEMBL
      E0CYH0
      Related
      ENSMUSP00000007007.8, ENSMUST00000007007.14
      Conserved Domains (1) summary
      pfam17098
      Location:68222
      Wtap; WTAP/Mum2p family
    3. NM_001379058.1NP_001365987.1  pre-mRNA-splicing regulator WTAP isoform a

      Status: VALIDATED

      Source sequence(s)
      AL589878
      Related
      ENSMUSP00000124205.2, ENSMUST00000159551.8
      Conserved Domains (1) summary
      pfam17098
      Location:68222
      Wtap; WTAP/Mum2p family
    4. NM_175394.2NP_780603.1  pre-mRNA-splicing regulator WTAP isoform b

      See identical proteins and their annotated locations for NP_780603.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate 5' UTR exon and lacks two exons, and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a different 3' UTR, compared to variant 1. It encodes isoform b which is C-terminal truncated, compared to isoform a. Variants 2 and 3 encode the same isoform b.
      Source sequence(s)
      AK031965, AK041341, AK076111
      Consensus CDS
      CCDS49949.1
      UniProtKB/Swiss-Prot
      Q9ER69
      Related
      ENSMUSP00000124138.2, ENSMUST00000160781.8
      Conserved Domains (1) summary
      pfam17098
      Location:68150
      Wtap; WTAP/Mum2p family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      13185686..13211430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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