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    Fignl1 fidgetin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 60530, updated on 18-Sep-2024

    Summary

    Official Symbol
    Fignl1provided by MGI
    Official Full Name
    fidgetin-like 1provided by MGI
    Primary source
    MGI:MGI:1890648
    See related
    Ensembl:ENSMUSG00000035455 AllianceGenome:MGI:1890648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable microtubule-severing ATPase activity. Involved in several processes, including male meiotic nuclear division; osteoblast differentiation; and osteoblast proliferation. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus and perinuclear region of cytoplasm. Is expressed in brain ventricular layer and inferior colliculus. Orthologous to human FIGNL1 (fidgetin like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14 (RPKM 22.0), liver E14.5 (RPKM 18.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fignl1 in Genome Data Viewer
    Location:
    11 A1; 11 7.08 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (11737429..11758962, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (11800288..11808983, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11557248-11557441 Neighboring gene predicted gene 11999 Neighboring gene STARR-positive B cell enhancer mm9_chr11:11590032-11590333 Neighboring gene IKAROS family zinc finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11611793-11612034 Neighboring gene predicted gene 12000 Neighboring gene STARR-positive B cell enhancer ABC_E5207 Neighboring gene STARR-positive B cell enhancer ABC_E3931 Neighboring gene STARR-positive B cell enhancer mm9_chr11:11666148-11666448 Neighboring gene STARR-positive B cell enhancer ABC_E6952 Neighboring gene STARR-seq mESC enhancer starr_28598 Neighboring gene STARR-seq mESC enhancer starr_28601 Neighboring gene STARR-seq mESC enhancer starr_28602 Neighboring gene dopa decarboxylase Neighboring gene predicted gene, 51937 Neighboring gene RIKEN cDNA 1700042O10 gene Neighboring gene STARR-seq mESC enhancer starr_28608

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule severing ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fidgetin-like protein 1
    NP_001156831.1
    NP_001156832.1
    NP_001412580.1
    NP_001412581.1
    NP_001412582.1
    NP_001412583.1
    NP_001412584.1
    NP_001412585.1
    NP_001412586.1
    NP_001412587.1
    NP_001412588.1
    NP_068691.2
    XP_036012780.1
    XP_036012781.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163359.2NP_001156831.1  fidgetin-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001156831.1

      Status: VALIDATED

      Source sequence(s)
      AL596450
      Consensus CDS
      CCDS24438.1
      UniProtKB/Swiss-Prot
      Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
      Related
      ENSMUSP00000126340.2, ENSMUST00000171938.2
      Conserved Domains (3) summary
      pfam09336
      Location:640680
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:599630
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:389574
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)
    2. NM_001163360.1NP_001156832.1  fidgetin-like protein 1

      See identical proteins and their annotated locations for NP_001156832.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK051874, AK143850, BY231020, CN693395
      Consensus CDS
      CCDS24438.1
      UniProtKB/Swiss-Prot
      Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
      Related
      ENSMUSP00000127489.2, ENSMUST00000171080.8
      Conserved Domains (3) summary
      pfam09336
      Location:640680
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:599630
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:389574
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)
    3. NM_001425651.1NP_001412580.1  fidgetin-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596450
    4. NM_001425652.1NP_001412581.1  fidgetin-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596450
    5. NM_001425653.1NP_001412582.1  fidgetin-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
    6. NM_001425654.1NP_001412583.1  fidgetin-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596450
    7. NM_001425655.1NP_001412584.1  fidgetin-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596450
    8. NM_001425656.1NP_001412585.1  fidgetin-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596450
    9. NM_001425657.1NP_001412586.1  fidgetin-like protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL596450
    10. NM_001425658.1NP_001412587.1  fidgetin-like protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL596450
    11. NM_001425659.1NP_001412588.1  fidgetin-like protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL596450
      Related
      ENSMUST00000152345.8
    12. NM_021891.4NP_068691.2  fidgetin-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_068691.2

      Status: VALIDATED

      Source sequence(s)
      AL596450
      Consensus CDS
      CCDS24438.1
      UniProtKB/Swiss-Prot
      Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
      Related
      ENSMUSP00000036932.5, ENSMUST00000047689.11
      Conserved Domains (3) summary
      pfam09336
      Location:640680
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:599630
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:389574
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

    RNA

    1. NR_189574.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL596450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      11737429..11758962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156888.1XP_036012781.1  fidgetin-like protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
      Conserved Domains (3) summary
      pfam09336
      Location:640680
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:599630
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:389574
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)
    2. XM_036156887.1XP_036012780.1  fidgetin-like protein 1 isoform X1

      Conserved Domains (3) summary
      pfam09336
      Location:649689
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:608639
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:398583
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)