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    Fignl1 fidgetin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 60530, updated on 12-Aug-2018

    Summary

    Official Symbol
    Fignl1provided by MGI
    Official Full Name
    fidgetin-like 1provided by MGI
    Primary source
    MGI:MGI:1890648
    See related
    Ensembl:ENSMUSG00000035455 Vega:OTTMUSG00000005160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in liver E14 (RPKM 22.0), liver E14.5 (RPKM 18.3) and 9 other tissues See more
    Orthologs

    Genomic context

    See Fignl1 in Genome Data Viewer
    Location:
    11; 11 A1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (11800288..11808995, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (11700291..11708965, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930512M02 gene Neighboring gene predicted gene 11999 Neighboring gene IKAROS family zinc finger 1 Neighboring gene RIKEN cDNA 1700042O10 gene Neighboring gene dopa decarboxylase Neighboring gene uncharacterized LOC102631979 Neighboring gene growth factor receptor bound protein 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule-severing ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163359.1NP_001156831.1  fidgetin-like protein 1

      See identical proteins and their annotated locations for NP_001156831.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK051874, AK143850, CN693395
      Consensus CDS
      CCDS24438.1
      UniProtKB/Swiss-Prot
      Q8BPY9
      Related
      ENSMUSP00000126340.1, ENSMUST00000171938.1
      Conserved Domains (3) summary
      smart00382
      Location:442578
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:446576
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:640680
      Vps4_C; Vps4 C terminal oligomerization domain
    2. NM_001163360.1NP_001156832.1  fidgetin-like protein 1

      See identical proteins and their annotated locations for NP_001156832.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK051874, AK143850, BY231020, CN693395
      Consensus CDS
      CCDS24438.1
      UniProtKB/Swiss-Prot
      Q8BPY9
      Related
      ENSMUSP00000127489.1, ENSMUST00000171080.7
      Conserved Domains (3) summary
      smart00382
      Location:442578
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:446576
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:640680
      Vps4_C; Vps4 C terminal oligomerization domain
    3. NM_021891.3NP_068691.2  fidgetin-like protein 1

      See identical proteins and their annotated locations for NP_068691.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK051874, AK086769, AK143850, CN693395
      Consensus CDS
      CCDS24438.1
      UniProtKB/Swiss-Prot
      Q8BPY9
      Related
      ENSMUSP00000036932.4, OTTMUSP00000005361, ENSMUST00000047689.10, OTTMUST00000011528
      Conserved Domains (3) summary
      smart00382
      Location:442578
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:446576
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:640680
      Vps4_C; Vps4 C terminal oligomerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      11800288..11808995 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514767.2XP_006514830.1  fidgetin-like protein 1 isoform X1

      Conserved Domains (3) summary
      smart00382
      Location:475611
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:479609
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:673713
      Vps4_C; Vps4 C terminal oligomerization domain
    2. XM_011243737.1XP_011242039.1  fidgetin-like protein 1 isoform X2

      Conserved Domains (3) summary
      smart00382
      Location:451587
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:455585
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:649689
      Vps4_C; Vps4 C terminal oligomerization domain
    3. XM_011243738.2XP_011242040.1  fidgetin-like protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011242040.1

      UniProtKB/Swiss-Prot
      Q8BPY9
      Conserved Domains (3) summary
      smart00382
      Location:442578
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:446576
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:640680
      Vps4_C; Vps4 C terminal oligomerization domain
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