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    Rbm8a RNA binding motif protein 8a [ Mus musculus (house mouse) ]

    Gene ID: 60365, updated on 18-Sep-2024

    Summary

    Official Symbol
    Rbm8aprovided by MGI
    Official Full Name
    RNA binding motif protein 8aprovided by MGI
    Primary source
    MGI:MGI:1913129
    See related
    Ensembl:ENSMUSG00000038374 AllianceGenome:MGI:1913129
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rbm8; 2310057C03Rik
    Summary
    Enables mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including central nervous system; future brain; and olfactory epithelium. Human ortholog(s) of this gene implicated in thrombocytopenia-absent radius syndrome. Orthologous to human RBM8A (RNA binding motif protein 8A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 30.4), CNS E14 (RPKM 14.6) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Rbm8a in Genome Data Viewer
    Location:
    3 F2.1; 3 41.93 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96537244..96541107)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96629928..96633791)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 34A Neighboring gene predicted gene, 52628 Neighboring gene RIKEN cDNA 6330549D23 gene Neighboring gene Lix1-like Neighboring gene STARR-positive B cell enhancer ABC_E7929 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:96439383-96439492 Neighboring gene peroxisomal biogenesis factor 11 beta Neighboring gene integrin, alpha 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA export from nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of U2-type catalytic step 1 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U2-type catalytic step 1 spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of exon-exon junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of exon-exon junction complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of exon-exon junction subcomplex mago-y14 ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    RNA-binding protein 8A
    Names
    RNA-binding motif protein 8A
    ribonucleoprotein RBM8A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102407.1NP_001095877.1  RNA-binding protein 8A isoform a

      See identical proteins and their annotated locations for NP_001095877.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC122037, AI845155, AK082925, CJ072219
      Consensus CDS
      CCDS51005.1
      UniProtKB/Swiss-Prot
      A0A023T672, Q3UT38, Q6GTD4, Q9CWZ3, Q9D6U5
      UniProtKB/TrEMBL
      A0A0N4SUH6
      Related
      ENSMUSP00000143190.2, ENSMUST00000196456.5
      Conserved Domains (1) summary
      cd12324
      Location:67151
      RRM_RBM8; RNA recognition motif (RRM) found in RNA-binding protein RBM8A, RBM8B nd similar proteins
    2. NM_025875.2NP_080151.2  RNA-binding protein 8A isoform b

      See identical proteins and their annotated locations for NP_080151.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC122037, AI845155, AK009953, CJ075560
      Consensus CDS
      CCDS79983.1
      UniProtKB/TrEMBL
      A0A0N4SUH6
      Related
      ENSMUSP00000044548.8, ENSMUST00000048915.11
      Conserved Domains (1) summary
      cd12324
      Location:66150
      RRM_RBM8; RNA recognition motif (RRM) found in RNA-binding protein RBM8A, RBM8B nd similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      96537244..96541107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)