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    Donson downstream neighbor of SON [ Mus musculus (house mouse) ]

    Gene ID: 60364, updated on 18-Sep-2024

    Summary

    Official Symbol
    Donsonprovided by MGI
    Official Full Name
    downstream neighbor of SONprovided by MGI
    Primary source
    MGI:MGI:1890621
    See related
    Ensembl:ENSMUSG00000022960 AllianceGenome:MGI:1890621
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORF60; 1110025J21Rik
    Summary
    Predicted to be involved in mitotic G2 DNA damage checkpoint signaling; nuclear DNA replication; and replication fork protection. Predicted to be located in replication fork. Predicted to be part of replisome. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb; and sensory organ. Orthologous to human DONSON (DNA replication fork stabilization factor DONSON). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 13.4), liver E14 (RPKM 10.6) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Donson in Genome Data Viewer
    Location:
    16 C3.3- C4; 16 53.25 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91463744..91485702, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91666856..91688932, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene phosphoribosylglycinamide formyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E3174 Neighboring gene STARR-positive B cell enhancer ABC_E7475 Neighboring gene predicted gene, 36712 Neighboring gene Son DNA binding protein Neighboring gene STARR-positive B cell enhancer ABC_E2468 Neighboring gene predicted gene 10785 Neighboring gene crystallin zeta like 1 Neighboring gene predicted gene, 46543

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic DNA replication checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic DNA replication checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nuclear DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replication fork processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
     
    located_in replication fork ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of replisome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of replisome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein downstream neighbor of Son
    Names
    protein 3SG

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021720.1NP_068366.1  protein downstream neighbor of Son

      See identical proteins and their annotated locations for NP_068366.1

      Status: PROVISIONAL

      Source sequence(s)
      BC043316
      Consensus CDS
      CCDS28330.1
      UniProtKB/Swiss-Prot
      Q80V93, Q8BV55, Q9QXP4
      UniProtKB/TrEMBL
      F6QFE2
      Related
      ENSMUSP00000023682.5, ENSMUST00000023682.12

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      91463744..91485702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523069.5XP_006523132.1  protein downstream neighbor of Son isoform X1

      See identical proteins and their annotated locations for XP_006523132.1

      UniProtKB/Swiss-Prot
      Q80V93, Q8BV55, Q9QXP4
      UniProtKB/TrEMBL
      F6QFE2