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    RNASE1 ribonuclease A family member 1, pancreatic [ Homo sapiens (human) ]

    Gene ID: 6035, updated on 5-Mar-2024

    Summary

    Official Symbol
    RNASE1provided by HGNC
    Official Full Name
    ribonuclease A family member 1, pancreaticprovided by HGNC
    Primary source
    HGNC:HGNC:10044
    See related
    Ensembl:ENSG00000129538 MIM:180440; AllianceGenome:HGNC:10044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAC1; RIB1; RNS1
    Summary
    This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in pancreas (RPKM 931.1), testis (RPKM 410.8) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RNASE1 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (20801228..20802844, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (14998670..15000286, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21269387..21271003, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984671 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:21240614-21241376 Neighboring gene NANOG hESC enhancer GRCh37_chr14:21243094-21243697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8095 Neighboring gene epididymal protein 3B Neighboring gene uncharacterized LOC105370397 Neighboring gene ribonuclease A family member k6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21281928-21282428 Neighboring gene Sharpr-MPRA regulatory region 8185 Neighboring gene Sharpr-MPRA regulatory region 4676 Neighboring gene MPRA-validated peak2113 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21296219-21297418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:21308316-21308816 Neighboring gene uncharacterized LOC100507513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8097 Neighboring gene NANOG hESC enhancer GRCh37_chr14:21372529-21373030 Neighboring gene ribonuclease A family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:21378679-21379180 Neighboring gene ribonuclease A family member 2C, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with ribonuclease, RNase A family, 1 (RNASE1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of RNase A ribonuclease 1 (RNASE1) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC12408

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribonuclease A activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    ribonuclease pancreatic
    Names
    HP-RNase
    RIB-1
    RNase 1
    RNase A
    RNase upI-1
    ribonuclease 1
    ribonuclease A C1
    ribonuclease, RNase A family, 1 (pancreatic)
    NP_002924.1
    NP_937875.1
    NP_937877.1
    NP_937878.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002933.5NP_002924.1  ribonuclease pancreatic precursor

      See identical proteins and their annotated locations for NP_002924.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is the predominant transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL133371, BC005324, BP385178
      Consensus CDS
      CCDS9559.1
      UniProtKB/Swiss-Prot
      B2R589, D3DS06, P07998, Q16830, Q16869, Q1KHR2, Q6ICS5, Q9UCB4, Q9UCB5
      UniProtKB/TrEMBL
      W0UV93
      Related
      ENSP00000381057.4, ENST00000397967.5
      Conserved Domains (1) summary
      smart00092
      Location:29152
      RNAse_Pc; Pancreatic ribonuclease
    2. NM_198232.3NP_937875.1  ribonuclease pancreatic precursor

      See identical proteins and their annotated locations for NP_937875.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes a different segment in the 5' UTR compared to variant 4. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AI400223, AL133371, BI753463
      Consensus CDS
      CCDS9559.1
      UniProtKB/Swiss-Prot
      B2R589, D3DS06, P07998, Q16830, Q16869, Q1KHR2, Q6ICS5, Q9UCB4, Q9UCB5
      UniProtKB/TrEMBL
      W0UV93
      Related
      ENSP00000399493.2, ENST00000412779.2
      Conserved Domains (1) summary
      smart00092
      Location:29152
      RNAse_Pc; Pancreatic ribonuclease
    3. NM_198234.3NP_937877.1  ribonuclease pancreatic precursor

      See identical proteins and their annotated locations for NP_937877.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional segment in the 5' UTR compared to variant 4. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL133371, AV710596, BC005324, BP385178
      Consensus CDS
      CCDS9559.1
      UniProtKB/Swiss-Prot
      B2R589, D3DS06, P07998, Q16830, Q16869, Q1KHR2, Q6ICS5, Q9UCB4, Q9UCB5
      UniProtKB/TrEMBL
      W0UV93
      Related
      ENSP00000344193.3, ENST00000340900.3
      Conserved Domains (1) summary
      smart00092
      Location:29152
      RNAse_Pc; Pancreatic ribonuclease
    4. NM_198235.3NP_937878.1  ribonuclease pancreatic precursor

      See identical proteins and their annotated locations for NP_937878.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) contains an additional segment in the 5' UTR compared to variant 4. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK098375, AL133371, BC005324, BC022882, BP385178
      Consensus CDS
      CCDS9559.1
      UniProtKB/Swiss-Prot
      B2R589, D3DS06, P07998, Q16830, Q16869, Q1KHR2, Q6ICS5, Q9UCB4, Q9UCB5
      UniProtKB/TrEMBL
      W0UV93
      Related
      ENSP00000381060.4, ENST00000397970.4
      Conserved Domains (1) summary
      smart00092
      Location:29152
      RNAse_Pc; Pancreatic ribonuclease

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      20801228..20802844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      14998670..15000286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)