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    RMRP RNA component of mitochondrial RNA processing endoribonuclease [ Homo sapiens (human) ]

    Gene ID: 6023, updated on 28-Jun-2021

    Summary

    Official Symbol
    RMRPprovided by HGNC
    Official Full Name
    RNA component of mitochondrial RNA processing endoribonucleaseprovided by HGNC
    Primary source
    HGNC:HGNC:10031
    See related
    Ensembl:ENSG00000269900 MIM:157660
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHH; NME1; RRP2; RMRPR
    Summary
    This gene encodes the RNA component of mitochondrial RNA processing endoribonuclease, which cleaves mitochondrial RNA at a priming site of mitochondrial DNA replication. This RNA also interacts with the telomerase reverse transcriptase catalytic subunit to form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase activity and produces double-stranded RNAs that can be processed into small interfering RNA. Mutations in this gene are associated with cartilage-hair hypoplasia.[provided by RefSeq, Mar 2010]
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    Genomic context

    See RMRP in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35657751..35658018, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35657748..35658015, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101926948 Neighboring gene signaling threshold regulating transmembrane adaptor 1 Neighboring gene coiled-coil domain containing 107 Neighboring gene Rho guanine nucleotide exchange factor 39 Neighboring gene RNA, 7SL, cytoplasmic 22, pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017041.1 RefSeqGene

      Range
      5001..5268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_163

    RNA

    1. NR_003051.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      DW422801, DW423815
      Related
      ENST00000602361.1

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      35657751..35658018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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