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    RGS2 regulator of G protein signaling 2 [ Homo sapiens (human) ]

    Gene ID: 5997, updated on 2-May-2024

    Summary

    Official Symbol
    RGS2provided by HGNC
    Official Full Name
    regulator of G protein signaling 2provided by HGNC
    Primary source
    HGNC:HGNC:9998
    See related
    Ensembl:ENSG00000116741 MIM:600861; AllianceGenome:HGNC:9998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G0S8
    Summary
    Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]
    Expression
    Broad expression in bone marrow (RPKM 211.2), adrenal (RPKM 208.4) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    1q31.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (192809039..192812275)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (192156109..192159345)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192778169..192781405)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371665 Neighboring gene integrin subunit beta 1 binding protein 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1654 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:192795712-192796911 Neighboring gene uncharacterized LOC105371668 Neighboring gene uncharacterized LOC105371667 Neighboring gene RN7SK pseudogene 126

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of RGS2 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
     
    enables adenylate cyclase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maternal process involved in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cardiac muscle hypertrophy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell growth involved in cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of glycine import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of phospholipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in relaxation of cardiac muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in relaxation of vascular associated smooth muscle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 2
    Names
    G0 to G1 switch regulatory 8, 24kD
    G0/G1 switch regulatory protein 8
    cell growth-inhibiting gene 31 protein
    cell growth-inhibiting protein 31
    regulator of G-protein signaling 2, 24kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012800.1 RefSeqGene

      Range
      5001..8237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002923.4NP_002914.1  regulator of G-protein signaling 2

      See identical proteins and their annotated locations for NP_002914.1

      Status: REVIEWED

      Source sequence(s)
      BC007049, BI912389, CD700013
      Consensus CDS
      CCDS1377.1
      UniProtKB/Swiss-Prot
      P41220, Q6I9U5
      Related
      ENSP00000235382.5, ENST00000235382.7
      Conserved Domains (1) summary
      cd08709
      Location:84197
      RGS_RGS2; Regulator of G protein signaling (RGS) domain found in the RGS2 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      192809039..192812275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      192156109..192159345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)