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    REG1B regenerating family member 1 beta [ Homo sapiens (human) ]

    Gene ID: 5968, updated on 5-Mar-2024

    Summary

    Official Symbol
    REG1Bprovided by HGNC
    Official Full Name
    regenerating family member 1 betaprovided by HGNC
    Primary source
    HGNC:HGNC:9952
    See related
    Ensembl:ENSG00000172023 MIM:167771; AllianceGenome:HGNC:9952
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    REGH; REGL; PSPS2; REGI-BETA
    Summary
    This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in duodenum (RPKM 280.8), small intestine (RPKM 149.9) and 2 other tissues See more
    Orthologs
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    Genomic context

    See REG1B in Genome Data Viewer
    Location:
    2p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (79085023..79087993, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (79085341..79088311, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (79312149..79315119, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:79220523-79221189 Neighboring gene regenerating family member 3 gamma Neighboring gene regenerating family member 1 alpha Neighboring gene regenerating family member 1 gamma, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    lithostathine-1-beta
    Names
    PSP-2
    REG-1-beta
    pancreatic stone protein 2
    regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein)
    regenerating islet-derived protein 1-beta
    regenerating protein I beta
    secretory pancreatic stone protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006507.4NP_006498.1  lithostathine-1-beta precursor

      See identical proteins and their annotated locations for NP_006498.1

      Status: REVIEWED

      Source sequence(s)
      CA867116, D16816
      Consensus CDS
      CCDS1963.1
      UniProtKB/Swiss-Prot
      P48304
      UniProtKB/TrEMBL
      Q6ICS1
      Related
      ENSP00000303206.3, ENST00000305089.8
      Conserved Domains (1) summary
      cl02432
      Location:36164
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      79085023..79087993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      79085341..79088311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)